Details of the Drug-Related molecule(s) Interaction Atlas

Indomethacin glucuronide Drug Info

Indomethacin acyl glucuronide; INDOMETHACIN GLUCURONIDE; CHEMBL2074828; Indomethacin Acyl-; INDOMETHACIN ACYL-B-D-GLUCURONIDE; 75523-11-4; ZINC84386263

Cross-matching ID

PubChem CID

70691027

CAS Number

CAS 75523-11-4

TTD Drug ID

DMSBENK

INTEDE Drug ID

DR2700

General Information of Drug (ID: DMSBENK)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Beta-glucuronidase (uidA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[3]
Conjugated Estrogens	DMLT0E1	Dyspareunia	GA12	Approved	[4]
SN-38G	DM2UVNB	N. A.	N. A.	Investigative	[5]
Ketoprofen glucuronide	DMX2FL3	N. A.	N. A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-glucuronidase (uidA)	DE9RA0I	BGLR_ECOLI	Substrate	[1]
Beta-glucuronidase (uidA)	DEGA738	BGLR_ECOLI	Substrate	[2]
Beta-glucuronidase (uidA)	DE68SAL	A0A174N6T8_BACVU	Substrate	[2]
Beta-glucuronidase (uidA)	DEKRUCA	A0A395VBK3_9FIRM	Substrate	[2]
Beta-glucuronidase (uidA)	DE473X0	A0A173S9G2_9FIRM	Substrate	[2]

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References

1	Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife. 2015 Dec 23;4:e08973.
2	Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.
3	Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7.
4	Long-term administration of conjugated estrogen and bazedoxifene decreased murine fecal beta-glucuronidase activity without impacting overall microbiome community. Sci Rep. 2018 May 25;8(1):8166.
5	Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats. Oncol Rep. 2008 Oct;20(4):727-30.
6	Bacterial beta-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica. 2014 Jan;44(1):28-35.