Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMST6A3)

Drug Name
Sodium pyruvate Drug Info
Synonyms
SODIUM PYRUVATE; 113-24-6; Pyruvic acid sodium salt; sodium 2-oxopropanoate; Pyruvic acid, sodium salt; Propanoic acid, 2-oxo-, sodium salt; Sodium alpha-ketopropionate; 2-Oxopropanoic acid sodium salt; UNII-POD38AIF08; POD38AIF08; CHEBI:50144; Natriumpyruvat; alpha-Ketopropionic acid sodium salt; MFCD00002586; Propanoic acid, 2-oxo-, sodium salt (1:1); S-6005; Pyruvic acid, sodium salt, 99+%; Pyruvate Sodium; Natrum pyruvicum; CHEMBL181886; sodiumpyruvate; Guna-flam; Guna-hypertension; EINECS 204-024-4; pyruvic acid na-salt; N-115; Sodium pyruvate (inhaled); Reactive oxygen species antagonist (inhaled), EmphyCorp; Sodium pyruvate (inhaled), EmphyCorp; PYRUVATE SODIUM
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Phase 1/2 [1]
Cross-matching ID
PubChem CID
23662274
ChEBI ID
CHEBI:50144
CAS Number
CAS 113-24-6
TTD Drug ID
DMST6A3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Reactive oxygen species (ROS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tafenoquine DM1XT4N Malaria 1F40-1F45 Approved [4]
Procysteine DMF9RB4 Amyotrophic lateral sclerosis 8B60.0 Phase 2 [5]
Mitoquinone DMKPZ0Q Hepatitis C virus infection 1E51.1 Phase 2 [6]
Drug(s) Targeting Carbonic anhydrase IV (CA-IV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [7]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [8]
Brinzolamide DMBAPFG Ocular hypertension 9C61.01 Approved [9]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [10]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [11]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [10]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [12]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [13]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [11]
SPERMINE DMD4BFY N. A. N. A. Terminated [14]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase IV (CA-IV) TTZHA0O CAH4_HUMAN Inhibitor [2]
Reactive oxygen species (ROS) TTULV0X NOUNIPROTAC Antagonist [3]

References

1 ClinicalTrials.gov (NCT00262652) Safety and Efficacy Study of the Use of Sodium Pyruvate Bronchodilation in Asthmatics. U.S. National Institutes of Health.
2 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):573-8.
3 A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol Pharmacol. 2006 Sep;70(3):925-35.
4 Tafenoquine: First Global Approval.Drugs. 2018 Sep;78(14):1517-1523.
5 Protective effect of procysteine on Acinetobacter pneumonia in hyperoxic conditions. J Antimicrob Chemother. 2013 Oct;68(10):2305-10.
6 Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels. Int J Mol Sci. 2020 Aug 27;21(17):6192.
7 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
8 Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.
9 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
11 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
12 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
13 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
14 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.