Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSZJUM)

Drug Name

SDZ-ISQ-844 Drug Info

Synonyms

143526-87-8; Sdz isq 844; Sdz-isq-844; SDZ ISQ-844; SCHEMBL7298437; AC1L317P; CTK4C3695; 3-Isoquinolinemethanol,1-(3,5-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-, (3S)-; AKOS030566039; 6,7-Dimethoxy-1-(3,4-dimethoxyphenyl)-3-hydroxymethyl-3,4-dihydroisoquinoline; (S)-1-(3,5-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-3-isoquinolinemethanol; 3-Isoquinolinemethanol, 1-(3,5-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-, (S)-

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Terminated	[1]

Cross-matching ID

PubChem CID: 132565
CAS Number: CAS 143526-87-8
TTD Drug ID: DMSZJUM

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Phosphodiesterase 3 (PDE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[3]
Oxtriphylline	DMLHSE3	Cough	MD12	Approved	[3]
Ibudilast	DM4LSPN	Castleman's disease	4B2Y	Approved	[4]
Enoximone	DMQVZJD	Congestive heart failure	BD10	Approved	[5]
Olprinone	DMWBQKU	Heart failure	BD10-BD13	Approved	[6]
Inamrinone Lactate	DMRMFP4	Cardiac disease	BA00-BE2Z	Approved	[7]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[3]
Tofisopam	DMTGNWU	Hyperuricaemia	5C55.Y	Phase 2	[8]
Tipelukast	DMS9BDQ	Asthma	CA23	Phase 2	[9]
RPL-554	DMLD4VQ	Allergic rhinitis	CA08.0	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 3 (PDE3)	TTZCG4L	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005292)
2	[Effects of SDZ ISQ 844, a cyclic nucleotide phosphodiesterase isozyme type III/IV inhibitor, on the release of histamine from human peripheral leukocytes].Arerugi.1997 May;46(5):426-32.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nat Rev Drug Discov. 2019 Oct;18(10):770-796.
5	In vitro and in vivo effects of the phosphodiesterase-III inhibitor enoximone on malignant hyperthermia-susceptible swine. Anesthesiology. 2003 Apr;98(4):944-9.
6	Olprinone: a phosphodiesterase III inhibitor with positive inotropic and vasodilator effects. Cardiovasc Drug Rev. 2002 Fall;20(3):163-74.
7	Effects of amrinone on hepatic ischemia-reperfusion injury in rats. J Hepatol. 2002 Jul;37(1):31-8.
8	The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm (Vienna). 2010 Nov;117(11):1319-25.
9	Company report (MediciNova)
10	Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.Lancet Respir Med.2013 Nov;1(9):714-27.