Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTJOEL)

• Drug Name: DIADENOSINE TETRAPHOSPHATE Drug Info
• Synonyms: Ap4A; F-1500 (tetraNa salt); Diadenosine 5',5''-P1,P4-tetraphosphate

Indication

Disease Entry	ICD 11	Status	REF
Cardiac arrhythmias	BC9Z	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 21706
  ChEBI ID: CHEBI:17422
  CAS Number: CAS 5542-28-9
  TTD Drug ID: DMTJOEL

Molecule-Related Drug Atlas

Drug(s) Targeting Adenosine receptor (ADOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[5]
NIR178	DMPER4A	Non-hodgkin lymphoma	2B33.5	Phase 2	[6]
M-216765	DMUIGM3	Hypertension	BA00-BA04	Terminated	[7]
GNF-PF-2224	DM26UKN	Discovery agent	N.A.	Investigative	[8]
8-sulfophenyl theophylline	DMOHB3Z	Discovery agent	N.A.	Investigative	[8]
SPT	DM94RJW	Discovery agent	N.A.	Investigative	[9]

Drug(s) Affected By Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (NUDT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[11]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[12]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By Bis(5'-nucleosyl)-tetraphosphatase (NUDT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[18]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine receptor (ADOR)	TTSLI08	NOUNIPROTAC	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bis(5'-nucleosyl)-tetraphosphatase (NUDT2)	OTMHM1DH	AP4A_HUMAN	Biotransformations	[3]
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (NUDT10)	OT61XMYC	NUD10_HUMAN	Regulation of Drug Effects	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1732).
• [2] Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1-adenosine receptors. Br J Pharmacol. 1996 Nov;119(5):835-44.
• [3] Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation. Int J Cancer. 2011 Apr 15;128(8):1770-82. doi: 10.1002/ijc.25505.
• [4] Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. BMC Biochem. 2002 Jul 16;3:20. doi: 10.1186/1471-2091-3-20.
• [5] Emerging adenosine receptor agonists. Expert Opin Emerg Drugs. 2007 Sep;12(3):479-92.
• [6] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [7] US patent application no. 2010,0009,934, Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders.
• [8] Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600.
• [9] Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts. J Mol Cell Cardiol. 1995 Mar;27(3):883-92.
• [10] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [11] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [12] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [13] Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
• [14] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [15] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [16] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [17] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [18] Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.