Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU08MN)

Drug Name

3'-Azido-3'-Deoxythymidine-5'-Monophosphate Drug Info

Synonyms

AZTMP; Zidovudine 5'-monophosphate; UNII-97YMU05VPJ; ZDVMP; AZT-MP; 3'-azido-3'-deoxythymidine-5'-monophosphate; 97YMU05VPJ; Zidovudine monophosphate; 3'-Azido-3'-deoxythymidine 5'-phosphate; 29706-85-2; 5'-Thymidylic acid, 3'-azido-3'-deoxy-; Zdv 5'-monophosphate; AzddTMP; 3'-azido-3'-deoxythymidine monophosphate; AZT-monophosphate; 3'-Azido-2',3'-deoxythymidine 5'-monophosphate; NSC742230; 3'-Azido-3'-deoxythymidine 5'phosphate; AC1Q6RVL; [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl d

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 65374
CAS Number: CAS 29706-85-2
TTD Drug ID: DMU08MN
INTEDE Drug ID: DR0009

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Mycobacterium Thymidine monophosphate kinase (MycB tmk)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[1]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[3]
2'-deoxythymidine triphosphate	DM9OEJT	Discovery agent	N.A.	Investigative	[1]
Deoxythymidine	DMR90HY	Discovery agent	N.A.	Investigative	[1]
Diphosphate	DMHY30B	Discovery agent	N.A.	Investigative	[1]
Thymidine-5'-Phosphate	DMKM6NQ	Discovery agent	N.A.	Investigative	[1]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate	DMM4VWD	Discovery agent	N.A.	Investigative	[4]
5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate	DMWVCJ1	Discovery agent	N.A.	Investigative	[1]
CHLORODEOXYURIDINE	DMQT3WJ	Discovery agent	N.A.	Investigative	[5]
BROMODEOXYURIDINE	DM0D7LA	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mycobacterium Thymidine monophosphate kinase (MycB tmk)	TT5B8AX	KTHY_MYCTU	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Thymidylate kinase (DTYMK)^{Main DME}	DEOTVYU	KTHY_HUMAN	Substrate	[2]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system. Redox Biol. 2017 Oct;13:407-417.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
5	Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial ac... Bioorg Med Chem. 2008 Jun 1;16(11):6075-85.