Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU1X8K)

Drug Name
GSK2820151 Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMU1X8K

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bromodomain and extraterminal domain protein (BET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CPI-0610 DMPXOYJ Myelofibrosis 2A20.2 Phase 3 [2]
ZEN-3694 DM6VQTF Prostate cancer 2C82.0 Phase 2 [3]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [2]
BMS-986158 DM6LDI4 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [2]
INCB054329 DM7TZL0 Refractory hematologic malignancy 2A85.5 Phase 1/2 [4]
INCB057643 DMG65CV Solid tumour/cancer 2A00-2F9Z Phase 1/2 [5]
ODM-207 DMOKVJD Solid tumour/cancer 2A00-2F9Z Phase 1/2 [6]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [7]
GSK525762 DMPAWBN Haematological malignancy 2B33.Y Phase 1 [2]
PLX51107 DMXLHVW Haematological malignancy 2B33.Y Phase 1 [2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain and extraterminal domain protein (BET) TTE4BSY NOUNIPROTAC Inhibitor [1]

References

1 ClinicalTrials.gov (NCT02630251) Dose Escalation Study of GSK2820151 in Subjects With Advanced or Recurrent Solid Tumors. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of Zenith Epigenetics.
4 The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies. Clin Cancer Res. 2019 Jan 1;25(1):300-311.
5 Development of 2 Bromodomain and Extraterminal Inhibitors With Distinct Pharmacokinetic and Pharmacodynamic Profiles for the Treatment of Advanced Malignancies. Clin Cancer Res. 2020 Mar 15;26(6):1247-1257.
6 First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours. Br J Cancer. 2020 Dec;123(12):1730-1736.
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)