Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUETI2)

Drug Name

AMG 167 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Sclerostin (SOST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romosozumab	DMFJZN0	Postmenopausal osteoporosis	FB83.11	Approved	[3]
UX143	DM89NIB	Osteogenesis imperfecta	LD24.K0	Phase 3	[4]
LY2541546	DMTVU2Q	Osteoporosis	FB83.0	Phase 2	[5]
BPS-804	DMDYZRS	Metabolic bone disease	FB8Y	Phase 2	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT01101048) An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With Low Bone Mineral Density. U.S. National Institutes of Health.
2	Osteoporosis - a current view of pharmacological prevention and treatment. Drug Des Devel Ther. 2013; 7: 435-448.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
4	Clinical pipeline report, company report or official report of Ultragenyx Pharmaceutical
5	Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol Sci. 2012 Feb;125(2):586-94.
6	WO patent application no. 2010,1001,79, Self-forming gel system for sustained drug delivery.