Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUG5OB)

Drug Name

CETi-1 Drug Info

Synonyms

Cholesteryl Ester Transfer Protein Vaccine; CETP vaccine, T Cell Sciences; Vaccine (CETP), AVANT; Vaccine (CETP), T Cell Sciences; Vaccine (atherosclerosis), T Cell Sciences

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Discontinued in Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMUG5OB

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Cholesteryl ester transfer protein (CETP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Evacetrapib	DMCDZ15	Cardiovascular disease	BA00-BE2Z	Phase 3	[3]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[4]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[5]
JTT-302	DMGLVBI	Lipid metabolism disorder	5C52.Z	Phase 2	[3]
DRL-17822	DMGD3XT	Arteriosclerosis	BD40	Phase 2	[3]
TA-8995	DMAZHT0	Cardiovascular disease	BA00-BE2Z	Phase 2	[6]
BAY-60-5521	DMXIDWE	Arteriosclerosis	BD40	Phase 1	[7]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[8]
CP-800569	DMZ0YU7	Arteriosclerosis	BD40	Discontinued in Phase 1	[9]
R7232	DMETAP8	Dyslipidemia	5C80-5C81	Discontinued in Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholesteryl ester transfer protein (CETP)	TTFQAYR	CETP_HUMAN	Not Available	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008445)
2	CETi-1. AVANT. Curr Opin Investig Drugs. 2004 Mar;5(3):334-8.
3	The dyslipidaemia market. Nat Rev Drug Discov. 2014 Nov;13(11):807-8.
4	Clinical pipeline report, company report or official report of Roche (2009).
5	Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and anacetrapib, a potent cholesteryl ester transfer protein (C... Br J Clin Pharmacol. 2009 May;67(5):520-6.
6	Amgen To Acquire Privately-Held Dezima Pharma
7	Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein. Br J Clin Pharmacol. 2012 Feb;73(2):210-8.
8	Safety and tolerability of dalcetrapib. Am J Cardiol. 2009 Jul 1;104(1):82-91.
9	Pfizer. Product Development Pipeline. March 31 2009.