Details of the Drug-Related molecule(s) Interaction Atlas

Acetyl ethylene Drug Info

Acetone, methylene-; 3-Buten-2-one; Butenone; Ketone, methyl vinyl; METHYL VINYL KETONE; Methyl ethenyl ketone; Methyl-vinyl-cetone; Methyl-vinyl-cetone [French]; Methylene acetone; Methylvinyl ketone; Methylvinylketon; Methylvinylketon [German]; Methylvinylketone; Vinyl methyl ketone; but-1-en-3-one; but-3-en-2-one; delta(sup 3)-2-Butenone; gamma-Oxo-alpha-butylene; methylvinylcetone; 1-Buten-3-one; 2-Butenone; 3-Butene-2-one; 3-Butenone-2; 3-oxo-1-butene; 78-94-4; CCRIS 3423; HSDB 716; NSC 4853; UNII-AR7642I1MP

Cross-matching ID

PubChem CID

6570

ChEBI ID

CHEBI:48058

CAS Number

CAS 78-94-4

TTD Drug ID

DMUH4N7

INTEDE Drug ID

DR2060

General Information of Drug (ID: DMUH4N7)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By NADPH:quinone reductase (CRYZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[2]
1,2-NAPHTHOQUINONE	DMYXELH	Discovery agent	N.A.	Investigative	[3]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[1]
Hexylacrolein	DMBC8KM	N. A.	N. A.	Investigative	[1]
J-009747	DMQSB6N	N. A.	N. A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
NADPH:quinone reductase (CRYZ)^{Main DME}	DE8RYV5	QOR_HUMAN	Substrate	[1]

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References

1	Kinetic and structural evidence of the alkenal/one reductase specificity of human crystallin. Cell Mol Life Sci. 2011 Mar;68(6):1065-77.
2	Role of glutathione reductase during menadione-induced NADPH oxidation in isolated rat hepatocytes. Biochem Pharmacol. 1987 Nov 15;36(22):3879-84.
3	Effect of superoxide dismutase on the autoxidation of various hydroquinones--a possible role of superoxide dismutase as a superoxide:semiquinone oxidoreductase. Free Radic Biol Med. 1988;5(2):71-9.