Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUR1FK)

Drug Name

Ecalcidene Drug Info

Synonyms

Vitamin D3 derivative, Barrier

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Vitamin D3 receptor (VDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[3]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[4]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[3]
Doxercalciferol	DM6FG1P	Chronic kidney disease	GB61	Approved	[5]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[6]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[7]
Dihydrotachysterol	DMFB97P	Hypocalcemia	5B5K.1	Approved	[8]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[9]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[10]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019289)
2	Degradation chemistry of a Vitamin D analogue (ecalcidene) investigated by HPLC-MS, HPLC-NMR and chemical derivatization. J Pharm Biomed Anal. 2006 Mar 3;40(4):850-63.
3	Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41.
4	Kaposi sarcoma is a therapeutic target for vitamin D(3) receptor agonist. Blood. 2000 Nov 1;96(9):3188-94.
5	Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.
6	Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation. Curr Drug Targets. 2008 Apr;9(4):345-59.
7	Synthesis and biological evaluations of A-ring isomers of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3. Bioorg Med Chem. 2000 Aug;8(8):2157-66.
8	In vivo metabolism of the vitamin D analog, dihydrotachysterol. Evidence for formation of 1 alpha,25- and 1 beta,25-dihydroxy-dihydrotachysterol metabolites and studies of their biological activity. J Biol Chem. 1993 Jan 5;268(1):282-92.
9	[Vitamin D2 or vitamin D3]. Rev Med Interne. 2008 Oct;29(10):815-20.
10	New acquisitions in therapy of secondary hyperparathyroidism in chronic kidney disease and peritoneal dialysis patients: role of vitamin D receptor... Contrib Nephrol. 2009;163:219-226.
11	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.