Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUWAM2)

Drug Name

Pyronaridine Drug Info

Synonyms

Malaridine; Pyronaridine phosphate salt; Benzonaphthyridine 7351; 2-Methoxy-7-chloro-10-(3',5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-1,5-naphthyridine; 4-((7-Chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)phenol; 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one; 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Approved	[1]

Cross-matching ID

PubChem CID: 107771
ChEBI ID: CHEBI:135951
CAS Number: CAS 74847-35-1
TTD Drug ID: DMUWAM2
VARIDT Drug ID: DR00605

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[2]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[2]
Piperaquine	DMT70RC	Malaria	1F40-1F45	Approved	[2]
Artemisinin SP	DMFETDK	Malaria	1F40-1F45	Approved	[2]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[2]
OZ277	DM1YB0R	Malaria	1F40-1F45	Approved	[2]
Vanadate	DMQL0KF	Psoriatic arthritis	FA21	Phase 3	[3]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[4]
Cyclopiazonic acid	DMPJ08G	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A)	TTZVSJ2	NOUNIPROTAC	Inhibitor	[2]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
3	Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms. J Biol Chem. 2001 Apr 6;276(14):10782-7.
4	Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase. Bioorg Med Chem. 2010 Aug 1;18(15):5634-46.