General Information of Drug (ID: DMV0MZ3)

Drug Name
FK-962 Drug Info
Synonyms FK-960 analog, Fujisawa
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 2 [1]
Cross-matching ID
PubChem CID
56842107
CAS Number
CAS 283167-06-6
TTD Drug ID
DMV0MZ3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
177Lu-DOTA-octreotate DMP5L8S Melanoma 2C30 Phase 3 [3]
177-Lu-oxodotreotide DMMZS2T Neuroendocrine cancer 2B72.1 Phase 3 [4]
177Lu-DOTATATE DMT8GVU Hepatitis C virus infection 1E51.1 Phase 2 [3]
Somatoprim DMTVS3A Acromegaly 5A60.0 Phase 2 [5]
Edotreotide DMQ08AJ Acromegaly 5A60.0 Phase 2 [6]
177Lu-labelled DOTA-JR11 DMVZ9XL Neuroendocrine cancer 2B72.1 Phase 1/2 [7]
212Pb-labelled DOTAMTATE DMN9MPX Neuroendocrine cancer 2B72.1 Phase 1 [8]
AlphaMedix DMBVM1Q Neuroendocrine cancer 2B72.1 Phase 1 [9]
FK-960 DMPD8O2 Cognitive impairment 6D71 Discontinued in Phase 2 [2]
SEGLITIDE DMXZVPH Pain MG30-MG3Z Discontinued in Phase 2 [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Somatostatin receptor (SSTR) TTOMNR9 NOUNIPROTAC Modulator [2]

References

1 ClinicalTrials.gov (NCT00087724) A Randomized Study to Evaluate FK962 in Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
2 FK960, a novel potential anti-dementia drug, enhances high K(+)-evoked release of somatostatin from rat hippocampal slices. Brain Res. 2001 Feb 16;892(1):111-7.
3 Peptide receptor radionuclide therapy with 177Lu-DOTATATE for patients with somatostatin receptor-expressing neuroendocrine tumors: the first US phase 2 experience. Pancreas. 2014 May;43(4):518-25.
4 Lutetium-labelled peptides for therapy of neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2012 Feb;39 Suppl 1(Suppl 1):S103-12.
5 DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours.Eur J Endocrinol.2012 Feb;166(2):223-34.
6 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
7 Multimodal Imaging of 2-Cycle PRRT with 177 Lu-DOTA-JR11 and 177 Lu-DOTATOC in an Orthotopic Neuroendocrine Xenograft Tumor Mouse Model. J Nucl Med. 2021 Mar;62(3):393-398.
8 Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608.
9 Clinical pipeline report, company report or official report of Orano Med.
10 Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria.. Br J Pharmacol. 1993 August; 109(4): 898-899.