Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVDCGZ)

Drug Name

Pyridoxamine Drug Info

Synonyms

Pyridorin (TN)

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Investigative Drug(s)

Clinical Trial Drug(s)

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Drug(s) Metabolized By Pyridoxamine-phosphate oxidase (PNPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyridoxine-5'-phosphate	DMFUNL1	Discovery agent	N.A.	Investigative	[5]
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Drug(s) Targeting Advanced glycosylation end product receptor (AGER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-4494700	DMJ7IKW	Alzheimer disease	8A20	Phase 3	[6]
Alagebrium chloride	DMD741P	Hypotension	BA20-BA21	Phase 2/3	[7]
TTP-448	DMR37X8	Alzheimer disease	8A20	Phase 2	[6]
TTP-4000	DMCG01R	Alzheimer disease	8A20	Phase 1	[8]
DBT-066	DMFYCQ1	Dementia	6D80-6D86	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Advanced glycosylation end product receptor (AGER)	TTMO9HF	RAGE_HUMAN	Inhibitor	[2] , [3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Pyridoxamine-phosphate oxidase (PNPO)^{Main DME}	DE3Z1RA	PNPO_HUMAN	Substrate	[4]

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References

1	ClinicalTrials.gov (NCT02156843) Pyridorin in Diabetic Nephropathy. U.S. National Institutes of Health.
2	Pyridoxamine, an inhibitor of advanced glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice. Protein Pept Lett. 2010 Sep;17(9):1177-81.
3	The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes. 2002 Sep;51(9):2826-32.
4	An LC-MS/MS-based method for the quantification of pyridox(am)ine 5'-phosphate oxidase activity in dried blood spots from patients with epilepsy. Anal Chem. 2017 Sep 5;89(17):8892-8900.
5	Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-beta signalling pathway in epithelial ovarian cancer. Cell Death Dis. 2017 Dec 13;8(12):3214.
6	Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's disease. Expert Opin Investig Drugs. 2015 Mar;24(3):393-9.
7	Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage. Trans Am Ophthalmol Soc. 2009 Dec;107:146-58.
8	Receptor for advanced glycation end products: its role in Alzheimer's disease and other neurological diseases. Future Neurol. 2009; 4(2): 167-177.
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2843).