Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVJL8W)

Drug Name
RG6299 Drug Info
Indication
Disease Entry ICD 11 Status REF
Geographic atrophy 9B75 Phase 2 [1]
IgA nephropathy MF8Y Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMVJL8W

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Complement factor B (CFB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Iptacopan DM9EZM0 Paroxysmal nocturnal haemoglobinuria 3A21.0 Approved [2]
LPN023 DM7BN5W IgA nephropathy MF8Y Phase 2 [3]
SAR443809 DMSUQTW Discovery agent N.A. Phase 1 [4]
CAB-2 DMQ4HUA Coronary artery disease BA80 Discontinued in Phase 1 [5]
TA-106 DME2PFQ Asthma CA23 Investigative [6]
PMID19743866C51 DMTX0ZJ Discovery agent N.A. Investigative [7]
NM-9308 DMC89HI Age-related macular degeneration 9B75.0 Investigative [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Complement factor B (CFB) TTA0P7K CFAB_HUMAN Not Available [1]

References

1 Clinical pipeline report, company report or official report of Roche
2 Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases. J Med Chem. 2020 Jun 11;63(11):5697-5722.
3 Complement Inhibitors in Clinical Trials for Glomerular Diseases. Front Immunol. 2019 Sep 27;10:2166.
4 Clinical pipeline report, company report or official report of Sanofi
5 A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation. 2002 Mar;9(2):125-34.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2339).
7 Structure-activity relationships for substrate-based inhibitors of human complement factor B. J Med Chem. 2009 Oct 8;52(19):6042-52.