Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVPWML)

Drug Name
2,4'-Diacetoxy-5,3'-di-(2-propenyl)-biphenyl Drug Info
Synonyms CHEMBL570311; Diacetylhonokiol; SCHEMBL18313888; BDBM50295922
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
45269978
TTD Drug ID
DMVPWML

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting LOX-5 messenger RNA (ALOX5 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TEBUFELONE DMMUE8P Pain MG30-MG3Z Discontinued in Phase 2 [2]
ZD-2138 DMVFCX7 Asthma CA23 Discontinued in Phase 2 [3]
BW A4C DMNUMDG Arthritis FA20 Terminated [4]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [5]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl DMWNJ84 Discovery agent N.A. Investigative [1]
METHYLHONOKIOL DM9YE6K Discovery agent N.A. Investigative [1]
HONOKIOL DMJWT3X Discovery agent N.A. Investigative [1]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [6]
PUUPEHENONE DMF3BCK Discovery agent N.A. Investigative [6]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
LOX-5 messenger RNA (ALOX5 mRNA) TTSJ6Q4 LOX5_HUMAN Inhibitor [1]

References

1 Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65.
2 New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflam... J Med Chem. 1998 Aug 27;41(18):3515-29.
3 Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg Med Chem. 2010 Jun 1;18(11):3910-24.
4 Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem. 2008 Sep 11;51(17):5449-53.
5 Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
6 Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.