Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW7XEU)

Drug Name

ALN-TMP Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Beta thalassemia	3A50.2	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting TMPRSS6 messenger RNA (TMPRSS6 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IONIS-TMPRSS6-LRx	DM7VJE1	Beta thalassemia	3A50.2	Phase 2	[2]
Sapablursen	DM95T5Z	Polycythemia vera	2A20.4	Phase 2	[3]
SLN124	DMIAOU6	Beta thalassemia	3A50.2	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TMPRSS6 messenger RNA (TMPRSS6 mRNA)	TTNIUKC	TMPS6_HUMAN	Inhibitor	[1]

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References

1	Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.
2	Clinical pipeline report, company report or official report of Ionis Pharmaceuticals.
3	Clinical pipeline report, company report or official report of Ionis
4	SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1. Hemasphere. 2019 Oct 1;3(6):e301.