Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWAR1T)

Drug Name
Ro 61-8048 Drug Info
Synonyms
199666-03-0; Ro61-8048; 3,4-dimethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonamide; Ro-61-8048; 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide; CHEMBL134915; 3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide; CHEBI:34953; C14126; MFCD11040807; 3,4-Dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide; C17H15N3O6S2; Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-; AC1NQZWG; 7ZR; SCHEMBL424256; AOB1234; DTXSID20415218; EX-A805; SYN5225; HMS3886F06; BCP07470; ZINC1546077; 4013AH; BDBM50061916; s8172; AKOS024457509; CCG-222062; CS-3332; NE62855; SB19626; NCGC00370730-07; NCGC00370730-09; NCGC00370730-13; AC-32906; AK312615; AS-16581; DA-43342; HY-12347; B7334; FT-0700256; EC-000.2437; Ro 61-8048, >=98% (HPLC); J-012900; Q27116332; 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide; 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide; 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzene-1-sulfonamide
Indication
Disease Entry ICD 11 Status REF
Neurodegenerative disorder 8A20-8A23 Preclinical [1]
Cross-matching ID
PubChem CID
5282337
ChEBI ID
CHEBI:34953
CAS Number
CAS 199666-03-0
TTD Drug ID
DMWAR1T

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Kynurenine 3-hydroxylase (KMO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK065 DMO87YS Pancreatitis DC31-DC34 Phase 1 [3]
Isoxazoles and isoxazoline derivative 2 DMKCYSD N. A. N. A. Patented [4]
Aryl pyrimidine derivative 7 DM8FAW3 N. A. N. A. Patented [4]
Isoxazoles and isoxazoline derivative 1 DMRML9B N. A. N. A. Patented [4]
Aryl pyrimidine derivative 2 DMU9Y4B N. A. N. A. Patented [4]
Cyclopropane 1-carboxylic acid derivative 6 DM0OMBW N. A. N. A. Patented [4]
PMID27172114-Compound-47 DMTIQYD N. A. N. A. Patented [4]
Isoxazoles and isoxazoline derivative 4 DMW3JZV N. A. N. A. Patented [4]
Cyclopropane 1-carboxylic acid derivative 2 DMSXB58 N. A. N. A. Patented [4]
Cyclopropane 1-carboxylic acid derivative 9 DMLH9AQ N. A. N. A. Patented [4]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kynurenine 3-hydroxylase (KMO) TTIY56R KMO_HUMAN Inhibitor [2]

References

1 Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
2 Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model. J Neurosci Res. 2020 Jan;98(1):155-167.
3 Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827.
4 Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32.