Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWGDXF)

Drug Name

TDI-0107 Drug Info

Synonyms

Gene therapy (SOD1 gene inhibitor), ALS Therapy Development Foundation

Indication

Disease Entry	ICD 11	Status	REF
Motor neurone disease	8B60	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Superoxide dismutase Cu-Zn (SOD Cu-Zn)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tofersen	DM0AEDT	Amyotrophic lateral sclerosis	8B60.0	Approved	[2]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[1]
Tempol	DMUQH78	Spinal cord injury	ND51.2	Phase 2	[3]
Superoxide dismutase	DMSWPA6	Myocardial infarction	BA41-BA43	Phase 2	[4]
Midismase	DMGCRKY	Cerebral infarction	8B11.5Z	Phase 2	[5]
Methoxyestradiol	DMHSL87	N. A.	N. A.	Phase 2	[6]
ATN-224	DMQJ5DV	Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]
PC-SOD	DMUHDX3	Interstitial lung disease	CB0Z	Phase 2	[5]
APN-201	DMV7Q6X	Dermatitis	EA80-EA89	Phase 1/2	[7]
EUK-189	DMY9ZAS	Skin burns	ME65.0	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Superoxide dismutase Cu-Zn (SOD Cu-Zn)	TT6RVLG	SODC_HUMAN	Inhibitor	[1]

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References

1	Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	The superoxide dismutase mimetic, tempol, reduces the bioavailability of nitric oxide and does not alter L-NAME-induced hypertension in rats. Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):29-34.
4	Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase: a novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant.Artif Cells Blood Substit Immobil Biotechnol.2011 Jun;39(3):127-36.
5	A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis
6	Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. J Biol Chem. 2003 Jan 3;278(1):407-14.
7	Peyronie's disease: a critical appraisal of current diagnosis and treatment. Int J Impot Res. 2008 Sep-Oct;20(5):445-59.
8	Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008;30(2):271-90.