Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWKZCY)

Drug Name

MRS2802 Drug Info

Synonyms

MRS2802

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting P2Y purinoceptor 14 (P2RY14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UDP-glucose	DMLT4JA	Discovery agent	N.A.	Investigative	[3]
UDP-glucuronic acid	DMW16X2	Discovery agent	N.A.	Investigative	[4]
PPTN	DML72JT	Discovery agent	N.A.	Investigative	[5]
2-thio-UDP	DM84R6C	Discovery agent	N.A.	Investigative	[2]
MRS2905	DMGCPHO	Discovery agent	N.A.	Investigative	[6]
MRS2690	DMNS3RT	Discovery agent	N.A.	Investigative	[7]
alpha.beta-methylene-2-thio-UDP	DMLGMTQ	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5909).
2	Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80.
3	Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs. Genomics. 2001 Dec;78(3):124-8.
4	Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8.
5	A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9.
6	Pharmacochemistry of the platelet purinergic receptors. Purinergic Signal. 2011 Sep;7(3):305-24.
7	The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013 Mar;9(1):31-40.