Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWZ6DK)

Drug Name

Roledumab Drug Info

Synonyms

DMATRIA; LFB-R593; R-297; R-593; Anti-D human monoclonal antibody, Laboratoire Francais du Fractionnement et des Biotechnologies; R297 antibody (hematological disease), LFB; R297 antibody (hematological disease), Laboratoire Francais du Fractionnement et des Biotechnologies; Anti-RhD antibody (hematological disease), LFB; Anti-rhesus D mAB (hematological disease), LFB

Indication

Disease Entry	ICD 11	Status	REF
Anemia	3A00-3A9Z	Phase 2/3	[1]

Cross-matching ID

TTD Drug ID: DMWZ6DK

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

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Drug(s) Targeting Blood group Rh(D) polypeptide (RHD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rozrolimupab	DMNBUS7	Anemia	3A00-3A9Z	Discontinued in Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Blood group Rh(D) polypeptide (RHD)	TTLCKI8	RHD_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT02287896) Pharmacokinetics and Safety of Roledumab, in RhD-negative Pregnant Women Carrying an RhD-positive Foetus. U.S. National Institutes of Health.
2	Pharmacokinetics and safety of roledumab, a novel human recombinant monoclonal anti-RhD antibody with an optimized Fc for improved engagement of FCgammaRIII, in healthy volunteers. Vox Sang. 2012 Oct;103(3):213-22.
3	Rozrolimupab, symphobodies against rhesus D, for the potential prevention of hemolytic disease of the newborn and the treatment of idiopathic thrombocytopenic purpura. Curr Opin Mol Ther. 2010 Dec;12(6):734-40.