Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX1D0S)

Drug Name
OMP-21M18 Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMX1D0S

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Delta-like protein 4 (DLL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dilpacimab DMCATH2 Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Navicixizumab DMZ2G69 Colorectal cancer 2B91.Z Phase 1 [4]
ABT-165 DMQ3O1U Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
NOV1501 DME2QUZ Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
REGN-421 DMWJ0IH Solid tumour/cancer 2A00-2F9Z Phase 1 [7]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Delta-like protein 4 (DLL4) TTV23LH DLL4_HUMAN Modulator [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8451).
2 National Cancer Institute Drug Dictionary (drug id 614677).
3 Apoptogenic activity of 2alpha,3alpha-dihydroxyurs-12-ene-28-oic acid from Prunella vulgaris var. lilacina is mediated via mitochondria-dependent activation of caspase cascade regulated by Bcl-2 in human acute leukemia Jurkat T cells. J Ethnopharmacol. 2011 Jun 1;135(3):626-35.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Synergistic antitumor activity of a DLL4/VEGF bispecific therapeutic antibody in combination with irinotecan in gastric cancer. BMB Rep. 2020 Nov;53(10):533-538.
7 J Clin Oncol 31, 2013 (suppl; abstr 2502).