Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX302C)

• Drug Name: BMS-690514 Drug Info
• Synonyms: BMS 690514; BMS690514

Indication

Disease Entry	ICD 11	Status	REF
Chronic pain	MG30	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 11349170
  CAS Number: CAS 859853-30-8
  TTD Drug ID: DMX302C

Molecule-Related Drug Atlas

Drug(s) Targeting Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[3]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[4]
Gefitinib	DM15F0X	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Erlotinib	DMCMBHA	Non-small-cell lung cancer	2C25.Y	Approved	[6]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[7]
Dacomitinib	DMOH8VY	Non-small-cell lung cancer	2C25.Y	Approved	[8]
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[9]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[10]
Epidermal growth factor	DMVONE6	Vulnerary	ND56.Z	Approved	[8]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[11]

Drug(s) Targeting Fms-like tyrosine kinase 3 (FLT-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[12]
Ponatinib	DMYGJQO	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Intedanib	DMSTA36	Colorectal cancer	2B91.Z	Approved	[14]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[7]
Gilteritinib	DMWQ4MZ	Acute myeloid leukaemia	2A60	Approved	[15]
Pexidartinib	DMS2J0Z	Tenosynovial giant cell tumour	2F7B	Approved	[16]
Lestaurtinib	DMQ2AIJ	Acute myeloid leukaemia	2A60	Approved (orphan drug)	[17]
Pacritinib	DM1T6ZN	Myelofibrosis	2A20.2	Phase 3	[12]
AC220	DM8Y4JS	Acute myeloid leukaemia	2A60	Phase 3	[18]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[19]

Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[20]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[21]
Regorafenib	DMHSY1I	Metastatic colorectal cancer	2B91	Approved	[13]
Sunitinib	DMCBJSR	Gastrointestinal cancer	2C11	Approved	[22]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[23]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[7]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[24]
Cabozantinib	DMIYDT4	Thyroid cancer	2D10	Approved	[25]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[26]
Lenvatinib	DMB1IU4	Thyroid cancer	2D10	Approved	[27]

Drug(s) Targeting ERBB2 messenger RNA (HER2 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HKI-272	DM6QOVN	Breast cancer	2C60-2C65	Phase 3	[28]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione	DMDO175	Discovery agent	N.A.	Investigative	[29]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[29]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[29]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[30]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[29]
PMID24915291C38	DMBXT9J	Discovery agent	N.A.	Investigative	[31]
Geldanamycin-estradiol hybrid	DMUSJ96	Discovery agent	N.A.	Investigative	[32]
CL-387785	DMLKFZC	Discovery agent	N.A.	Investigative	[33]
HDS-029	DMLRUVA	Discovery agent	N.A.	Investigative	[33]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Epidermal growth factor receptor (EGFR)	TTGKNB4	EGFR_HUMAN	Inhibitor	[2]
ERBB2 messenger RNA (HER2 mRNA)	TTR5TV4	ERBB2_HUMAN	Inhibitor	[2]
Fms-like tyrosine kinase 3 (FLT-3)	TTGJCWZ	FLT3_HUMAN	Inhibitor	[2]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[2]

References

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• [25] Clinical pipeline report, company report or official report of Exelixis (2011).
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• [28] Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41.
• [29] Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81.
• [30] Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43.
• [31] Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28.
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