Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX6AJ8)

Drug Name

ZM-H1505R Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis B	1E51	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Hepatitis B virus Capsid protein (HBV C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JNJ-56136379	DM9RW6H	Hepatitis B	1E51	Phase 2	[3]
ABI-H2158	DM6X70G	Hepatitis B	1E51	Phase 2	[4]
ABI-H0731	DMX1KDM	Hepatitis B	1E51	Phase 2	[5]
ABI-H3733	DM4TN6W	Hepatitis B	1E51	Phase 1	[4]
EDP-514	DM8KRA3	Chronic HBV infection	1E51.0Z	Phase 1	[6]
RG7907	DMKVIS5	Hepatitis B	1E51	Phase 1	[7]
A204	DMF1LYP	Hepatitis B virus infection	1E51.0	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis B virus Capsid protein (HBV C)	TTM42UJ	CAPSD_HBVD3	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04220801) A Study of Orally Administered ZM-H1505R to Evaluate Safety, Tolerability and Pharmacokinetics After Single and Multiple Ascending Doses in Healthy Participants. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Shanghai Zhimeng Biopharma.
3	JNJ-56136379, an HBV Capsid Assembly Modulator, Is Well-Tolerated and Has Antiviral Activity in a Phase 1 Study of Patients With Chronic Infection. Gastroenterology. 2020 Aug;159(2):521-533.e9.
4	Clinical pipeline report, company report or official report of Assembly Biosciences.
5	Safety, pharmacokinetics, and antiviral effects of ABI-H0731, a hepatitis B virus core inhibitor: a randomised, placebo-controlled phase 1 trial. Lancet Gastroenterol Hepatol. 2020 Feb;5(2):152-166.
6	Clinical pipeline report, company report or official report of Enanta Pharmaceuticals.
7	Clinical pipeline report, company report or official report of Roche.
8	Clinical pipeline report, company report or official report of Klus Pharma