Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX9AGF)

Drug Name
GRL0617 Drug Info
Synonyms
5-Amino-2-Methyl-N-[(1r)-1-Naphthalen-1-Ylethyl]benzamide; GRL-0617; 5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide; 5-Amino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide; 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)-benzamide; CHEMBL549695; SCHEMBL1319181; BDBM31524; GTPL11078; CHEBI:167176; 5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide; EX-A4032; GRL 0617; s6845; ZINC43012570; AKOS015840255; AKOS015924263; DB08656; compound 25 [PMID: 19645480]; NCGC00188640-01; Naphthalene and Benzamide Derivative, 25; HY-117043; CS-0063568; Q27097846
Indication
Disease Entry ICD 11 Status REF
Coronavirus infection 1D92 Preclinical [1]
Cross-matching ID
PubChem CID
24941262
ChEBI ID
CHEBI:167176
TTD Drug ID
DMX9AGF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting COVID-19 papain-like proteinase (PL-PRO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [3]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [3]
PX-12 DMLVHAJ Pancreatic cancer 2C10 Phase 2 [3]
Tideglusib DME4LA1 Alzheimer disease 8A20 Phase 2 [3]
Hexylcarbamoyl fluorouracil DMYNPK8 Solid tumour/cancer 2A00-2F9Z Withdrawn from market [3]
PMID26868298-compound-N3 DMQFUCD Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [3]
Isoarnebin 4 DM0B7NO Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [3]
PMID32321856-compound-11a DMN39V6 Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [5]
PMID32321856-compound-11b DM31QEY Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
COVID-19 papain-like proteinase (PL-PRO) TTNHMO8 R1AB_SARS2 (819-2763) Inhibitor [2]

References

1 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
2 Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B. 2021 Jan;11(1):237-245.
3 Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9.
4 ClinicalTrials.gov (NCT04361422) Isotretinoin in Treatment of COVID-19. U.S. National Institutes of Health.
5 Structure-based Design of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease. Science. 2020 Apr 22;eabb4489.