Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXH1KC)

Drug Name

CL-316,243 Drug Info

Synonyms

UNII-52H8DB0TKX; 52H8DB0TKX; 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid; CL-316243; 5-((2R)-2-(((2R)-2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)-1,3-benzodioxole-2,2-dicarboxylic acid; CL 316243; CL316,243; Cl-316243 Free diacid; AC1NUOLQ; Lopac0_000295; SCHEMBL2345491; GTPL3462; CHEMBL1204876; BDBM25763; ZINC1493298; 183720-02-7; 1,3-Benzodioxole-2,2-dicarboxylic acid, 5-((2R)-2-(((2R)-2-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-; LS-187111

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Phase 2	[1]

Cross-matching ID

PubChem CID: 5312115
CAS Number: CAS 138908-40-4
TTD Drug ID: DMXH1KC

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Adrenergic receptor beta-3 (ADRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mirabegron	DMS1GYT	Overactive bladder	GC50.0	Approved	[4]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[5]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[6]
Bopindolol	DMIFYLX	Hypertension	BA00-BA04	Approved	[7]
Mepindolol	DMUDWP9	Angina pectoris	BA40	Approved	[8]
Rimiterol	DMA47C6	Asthma	CA23	Approved	[9]
Bitolterol	DMK6XAV	Chronic obstructive pulmonary disease	CA22	Approved	[10]
Nipradilol	DMA65ER	Angina pectoris	BA40	Approved	[11]
Vibegron	DMFR201	Overactive bladder	GC50.0	Approved	[12]
ONO-2506	DMCA2PJ	Stroke	8B20	Phase 2/3	[13]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Mitochondrial uncoupling protein 2 (UCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NC-2100	DMJKZUC	Discovery agent	N.A.	Investigative	[14]
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Drug(s) Targeting Mitochondrial uncoupling protein 1 (UCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NC-2100	DMJKZUC	Discovery agent	N.A.	Investigative	[14]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-3 (ADRB3)	TTMXGCW	ADRB3_HUMAN	Agonist	[2]
Mitochondrial uncoupling protein 1 (UCP1)	TTI12YJ	UCP1_HUMAN	Inducer	[3]
Mitochondrial uncoupling protein 2 (UCP2)	TTSC2YM	UCP2_HUMAN	Inducer	[3]
Mitochondrial uncoupling protein 3 (UCP3)	TT12RJK	UCP3_HUMAN	Inducer	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3462).
2	Beta 3-adrenoceptor agonists as anti-diabetic and anti-obesity drugs in humans. Curr Pharm Des. 2001 Sep;7(14):1433-49.
3	Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37.
4	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
5	Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
6	Effects of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on ischemic myocardial energy metabolism in dogs. J Pharm Sci. 1993 Mar;82(3):291-5.
7	Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes. J Cardiovasc Pharmacol. 1986;8 Suppl 6:S70-3.
8	Pharmacological studies on the intrinsic sympathomimetic activity of the beta-adrenoceptor antagonist mepindolol. Arzneimittelforschung. 1986 May;36(5):811-3.
9	Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man. Br J Clin Pharmacol. 1975 Feb;2(1):41-8.
10	Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma. Pharmacotherapy. 1985 May-Jun;5(3):127-37.
11	Actions of nipradilol (K-351), a new alpha- and beta-adrenoceptor blocker, on the rabbit portal vein. Jpn J Pharmacol. 1984 Aug;35(4):359-69.
12	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
13	FR149175, a beta 3-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus. Jpn J Pharmacol. 1997 May;74(1):109-12.
14	A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes. 2000 May;49(5):759-67.