Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXNR04)

• Drug Name: Unoprostone Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Glaucoma/ocular hypertension	9C61	Approved	[1]
Ocular hypertension	9C61.01	Approved	[2]
Retinitis pigmentosa	9B70	Approved	[2]

• Cross-matching ID:
  PubChem CID: 5311236
  ChEBI ID: CHEBI:39455
  CAS Number: CAS 120373-36-6
  TTD Drug ID: DMXNR04

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin receptor (PTGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bimatoprost	DMX0E5B	Alopecia	ED70	Approved	[4]
Iclaprim	DM7YNV9	Bacterial infection	1A00-1C4Z	Phase 3	[5]
JB991	DMKU6MW	Skin infection	1F28-1G0Z	Phase 2	[6]
Taprostene	DMA4WY5	Thrombosis	DB61-GB90	Discontinued in Phase 3	[7]
ZD-4953	DM5UCHW	Pain	MG30-MG3Z	Discontinued in Phase 2	[8]
TEI-6122	DM3F5E0	Diabetic complication	5A2Y	Discontinued in Phase 2	[9]
YP-009	DMPXLG2	Solid tumour/cancer	2A00-2F9Z	Terminated	[10]
YP-008	DM2N76V	Psoriasis vulgaris	EA90	Terminated	[11]
IP-1200	DMIX7CP	Erectile dysfunction	HA01.1	Investigative	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin receptor (PTGR)	TT9B4N3	NOUNIPROTAC	Modulator	[3]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Unoprostone FDA Label
• [3] Comparison of the vasoactive effects of the docosanoid unoprostone and selected prostanoids on isolated perfused retinal arterioles. Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1499-504.
• [4] Bimatoprost-induced calcium signaling in human T-cells does not involve prostanoid FP or TP receptors. Curr Eye Res. 2009 Mar;34(3):184-95.
• [5] Novel ocular antihypertensive compounds in clinical trials. Clin Ophthalmol. 2011; 5: 667-677.
• [6] US patent application no. 2006,0041,016, Composition and method for the treatment of psoriasis.
• [7] Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse. J Cardiovasc Pharmacol. 2004 Jun;43(6):795-807.
• [8] WO patent application no. 2013,1675,82, Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease.
• [9] The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells.. Br J Pharmacol. 1995 October; 116(4): 2298-2302.
• [10] YP 009 York Pharma pc preclinical, UK(cancer), R & D Focus Drug News, November 12, 2007
• [11] CA patent application no. 841416, Method of selecting therapeutic indications.
• [12] Clinical pipeline report, company report or official report of Immunologic.