Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXVHOQ)

Drug Name

GNE684 Drug Info

Synonyms

(5S)-N-[(3S)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide; HY-128585; CS-0095948; (s)-N-((s)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1h-pyrido[3,4-b]azepin-3-yl)-5-phenyl-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide; 2438637-64-8; L8D; rel-(S)-N-((S)-7-Methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[3,4-b]azepin-3-yl)-5-phenyl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Preclinical	[1]

Cross-matching ID

PubChem CID: 138377384
TTD Drug ID: DMXVHOQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Receptor-interacting protein 1 (RIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK2982772	DM7HNFV	Plaque psoriasis	EA90.0	Phase 2	[3]
DNL758	DM89D6C	Cutaneous lupus erythematosus	EB5Z	Phase 2	[4]
Eclitasertib	DM2O8VW	Ulcerative colitis	DD71	Phase 2	[5]
SAR443820	DMNCP7B	Amyotrophic lateral sclerosis	8B60.0	Phase 2	[6]
GSK3145095	DM059OH	Pancreatic cancer	2C10	Phase 1/2	[7]
R552	DM5XCRQ	Nervous system paraneoplastic or autoimmune disorders	8E4A.1	Phase 1	[4]
DNL747	DMNSC0O	Alzheimer disease	8A20	Phase 1	[4]
DNL104	DMOSCQ9	Alzheimer disease	8A20	Phase 1	[8]
Tricyclic compound 10	DMV1RQX	N. A.	N. A.	Patented	[9]
Tricyclic compound 8	DMZI8GK	N. A.	N. A.	Patented	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Receptor-interacting protein 1 (RIPK1)	TTAIQSN	RIPK1_HUMAN	Inhibitor	[2]

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References

1	RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases. Cell Death Differ. 2020 Jan;27(1):161-175.
2	Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death. Cell Death Differ. 2021 Mar;28(3):985-1000.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target. Nat Rev Drug Discov. 2020 Aug;19(8):553-571.
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
6	ClinicalTrials.gov (NCT05237284) A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of SAR443820 in Adult Participants With Amyotrophic Lateral Sclerosis, Followed by an Open-label Extension. U.S.National Institutes of Health.
7	Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862.
8	DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. Clin Pharmacol Ther. 2020 Feb;107(2):406-414.
9	Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents.Expert Opin Ther Pat. 2016 Nov;26(11):1239-1256.