General Information of Drug (ID: DMXWD08)

Drug Name
(R)-Xamoterol Drug Info
Cross-matching ID
PubChem CID
155774
ChEBI ID
CHEBI:10055
CAS Number
CAS 81801-12-9
TTD Drug ID
DMXWD08
VARIDT Drug ID
DR01670

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [2]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [3]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [4]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [5]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Verapamil DMA7PEW Angina pectoris BA40 Approved [7]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [8]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [9]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [10]
Propranolol DM79NTF Angina pectoris BA40 Approved [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [1]

References

1 Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42.
2 Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
3 Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86.
4 Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42.
5 Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57.
6 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
7 Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33.
8 Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
9 Comparison of type I and type II organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
10 Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53.
11 Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.