Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXZNB2)

Drug Name

KNI-102 Drug Info

Synonyms

Kni-102; Kni 102; 139694-65-8; Rpi 312; CHEBI:80005; AHPBA 1a; Z-Asn-apns-pro-NH-t-but; RPI-312; Cbz-Asn-Apns-Pro-NH-tBu; AC1Q5L2D; BDBM4215; AC1L22E8; SCHEMBL2771668; Z-Asparaginyl-allophenylnorstatinyl-t-butylproline amide; CHEMBL3349847; DTXSID70161152; 1-(3-(N-alpha-Benzyloxycarbonyl-L-asparaginyl)amino-2-hydroxy-4-phenylbutyryl)-N-tert-butyl-L-prolinamide; C15654; benzyl N-[(2S)-4-amino-1-[[(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]amino]-1,4-dioxobutan-2-yl]carbamate

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Terminated	[1]

Cross-matching ID

PubChem CID: 65004
ChEBI ID: CHEBI:80005
CAS Number: CAS 139694-65-8
TTD Drug ID: DMXZNB2

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Protease (HIV PR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[3]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[4]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[5]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[6]
Amprenavir	DMLMXE0	Human immunodeficiency virus infection	1C62	Approved	[7]
Darunavir	DMN3GCH	Human immunodeficiency virus infection	1C62	Approved	[8]
Tipranavir	DM8HJX6	Human immunodeficiency virus infection	1C62	Approved	[9]
Fosamprenavir	DM4W9B3	Human immunodeficiency virus infection	1C62	Approved	[10]
BI 201335	DM3MXT8	Hepatitis C virus infection	1E51.1	Phase 3	[11]
BMS 650032	DMQI43G	Hepatitis C virus infection	1E51.1	Phase 2	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Protease (HIV PR)	TT5FNQT	POL_HV1B1	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002506)
2	KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic. Chem Pharm Bull (Tokyo). 1991 Nov;39(11):3088-90.
3	PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63.
4	Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liq... J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):575-80.
5	Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009 Apr;33(4):307-20.
6	Hollow-fiber unit evaluation of a new human immunodeficiency virus type 1 protease inhibitor, BMS-232632, for determination of the linked pharmacod... J Infect Dis. 2001 Apr 1;183(7):1126-9.
7	Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503.
8	2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
9	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10	Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in ... J Antimicrob Chemother. 2009 Aug;64(2):398-410.
11	2011 Pipeline of Boehringer Ingelheim Pharma.
12	2011 Pipeline of Bristol-Myers Squibb.