Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY293M)

Drug Name

PEG-LPA-2 Drug Info

Synonyms

Leptin receptor antagonists (cancer/endometriosis); Leptin receptor antagonists (cancer/endometriosis), CRT; Leptin receptor antagonists (cancer/endometriosis), Cancer Research Technology; PEGylated leptin receptor antagonists (cancer/endometriosis), CRT; PEGylated leptin receptor antagonists (cancer/endometriosis), Cancer Research Technology

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMY293M

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Leptin receptor (LEPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metreleptin	DM1NOEK	Acquired generalized lipodystrophy		Approved	[2]
AMPE4L	DM64X25	Diabetic complication	5A2Y	Investigative	[1]
PEGylated leptin	DMZ01PS	Obesity	5B81	Investigative	[1]
BL-5040	DMGULNZ	Cachexia	MG20	Investigative	[1]
ANG-2004	DMK1IMC	Obesity	5B81	Investigative	[1]
AMPSL	DMXRIUT	Diabetic complication	5A2Y	Investigative	[1]
Leptin	DM5LY1H	Alzheimer disease	8A20	Investigative	[1]
EDP-21	DMMN0GO	Obesity	5B81	Investigative	[1]
AMPPL	DMVHOQE	Diabetic complication	5A2Y	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leptin receptor (LEPR)	TT0HD6V	LEPR_HUMAN	Antagonist	[1]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712).
2	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.