Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYZRTB)

Drug Name

Nojirimycine Tetrazole Drug Info

Synonyms

nojirimycine tetrazole; (5R,6R,7S,8S)-5-(hydroxymethyl)-5,6,7,8-tetrahydrotetrazolo[1,5-a]pyridine-6,7,8-triol; Gluco-tetrazole; 1noi; 1nok; 1noj; 2j7b; AC1L9HNU; ZINC17193216

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 445245
TTD Drug ID: DMYZRTB

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Lactase-phlorizin hydrolase (LCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[2]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[2]
2,5-dideoxy-2,5-imino-D-altritol	DMI1O54	Discovery agent	N.A.	Investigative	[3]
Gluconolactone	DMO071E	Discovery agent	N.A.	Investigative	[1]
ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE	DM0O4A2	Discovery agent	N.A.	Investigative	[1]
Hyacinthacine B3	DMJ9KNU	Discovery agent	N.A.	Investigative	[4]
D-Gluconhydroximo-1,5-Lactam	DM527XP	Discovery agent	N.A.	Investigative	[1]
2,5-dideoxy-2,5-imino-dl-glycero-D-manno-heptitol	DMKP7O0	Discovery agent	N.A.	Investigative	[5]
2-Deoxy-2fluoro-Glucose	DMMC8IG	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Glycogen phosphorylase muscle form (GP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[6]
JTT-651	DMGP42Q	Type-2 diabetes	5A11	Discontinued in Phase 1	[7]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[2]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[2]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[2]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[2]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[2]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[2]
OLEANOLIC_ACID	DMWDMJ3	Discovery agent	N.A.	Investigative	[8]
Oleanonic acid	DMYPJC3	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[1]
Lactase-phlorizin hydrolase (LCT)	TTA0OSE	LPH_HUMAN	Inhibitor	[1]

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References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem. 2010 Jun 1;18(11):3790-4.
4	New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. J Nat Prod. 2002 Dec;65(12):1875-81.
5	Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis. J Nat Prod. 1998 May;61(5):625-8.
6	Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8.
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026877)
8	Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54.