Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZJP2T)

Drug Name

INCB50465 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Diffuse large B-cell lymphoma	2A81	Phase 2	[1]
Follicular lymphoma	2A80	Phase 2	[1]
Mantle cell lymphoma	2A85.5	Phase 2	[1]
Marginal zone lymphoma	2A85.0	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting PI3-kinase delta (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[2]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[3]
Umbralisib	DMYRBO1	Follicular lymphoma	2A80	Approved	[4]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[5]
Leniolisib	DMWAD93	Stomach cancer	2B72	Approved	[6]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[7]
ME-401	DMK0UOY	Follicular lymphoma	2A80	Phase 2	[1]
RP6530	DMYILGK	Chronic lymphocytic leukaemia	2A82.0	Phase 2	[1]
Parsaclisib	DMYBIFS	Follicular lymphoma	2A80	Phase 2	[8]
AZD8154	DMK13L1	Asthma	CA23	Phase 2	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
3	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
5	PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74.
6	Effective "activated PI3K syndrome"-targeted therapy with the PI3K inhibitor leniolisib. Blood. 2017 Nov 23;130(21):2307-2316.
7	Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44.
8	Parsaclisib, a potent and highly selective PI3K inhibitor, in patients with relapsed or refractory B-cell malignancies. Blood. 2019 Apr 18;133(16):1742-1752.
9	Discovery of AZD8154, a Dual PI3Kgamma-delta Inhibitor for the Treatment of Asthma. J Med Chem. 2021 Jun 24;64(12):8053-8075.