Details of the Drug Reposition

General Information of This Drug (ID: DM2JGQ3)

Drug Name
Trametinib   DM2JGQ3
Synonyms
GSK 1120212; GSK-1120212; GSK1120212; JTP 74057; JTP-74057; Mekinist; Trametinib (GSK1120212); Trametinib (GSK1120212JTP 74057); Trametinib (MEK inhibitor); 33E86K87QN; A1-01871; AK174783; CHEBI:75998; UNII-33E86K87QN
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
2 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Melanoma DIS1RRCY 2C30 Approved [1]
Metastatic melanoma DISSL43L 2E2Z Approved [2]
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1 Withdrawn Indication(s)
Indication Name Indication ID ICD-11 Status REF
Papillary serous cystadenocarcinoma DISZV6Z3 N.A. Withdrawn [3]
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1 Discontinued in Phase 3 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Poorly differentiated thyroid gland carcinoma DISPBT1J N.A. Discontinued in Phase 3 [4]
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1 Discontinued in Phase 2 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Ovarian serous adenocarcinoma DISSU72Z N.A. Discontinued in Phase 2 [5]
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1 Discontinued in Phase 1 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Primary peritoneal serous adenocarcinoma DISNCHKN N.A. Discontinued in Phase 1 [6]
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2 Investigative Indication(s)
Indication Name Indication ID ICD-11 Status REF
Middle East Respiratory Syndrome (MERS) DIS5VPYU 1D64 Investigative [7]
Severe acute respiratory syndrome (SARS) DISYW14W 1D65 Investigative [7]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6495).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 ClinicalTrials.gov (NCT01763541) Study of the Effect of Testosterone and Estradiol on NP Responses to Acute and Chronic Salt Loading
4 Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer
5 A Study of Everolimus in Combination With Imatinib in Metastatic Melanoma
6 Dose Escalation Trial of Denileukin Diftitox (Ontak) Post Autologous Transplantation
7 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.