Details of the Drug

General Information of Drug (ID: DM0WD1V)

Drug Name
Human calcitonin
Synonyms Calcitonin (human synthetic); Calcitonin (human); Calcitonin human; Calcitonin, human; Calcitonin, human synthetic
Sequence
CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP
Structure
3D MOL is unavailable 2D MOL
ADMET Property
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 1.3 mg/L []
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 4 h []
Bioavailability
The bioavailability of drug is 57% []
Clearance
The renal clearance of drug is 1.96 mL/min [1]
Half-life
The concentration or amount of drug in body reduced by one-half in 10.2 - 37.8 minutes [2]
Metabolism
The drug is metabolized via the kidney [3]
Cross-matching ID
PubChem CID
16220016
DrugBank ID
DB06773
INTEDE ID
DR0811

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Alanyl aminopeptidase (ANPEP) DE7PT32 AMPN_HUMAN Substrate [4]
Phosphoglucomutase 1 (PGM1) DEA3VM1 PGM1_HUMAN Substrate [4]
Alpha-N-acetylglucosaminidase (NAG) DELOWRJ ANAG_HUMAN Substrate [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Tiegs RD, Body JJ, Barta JM, Heath H 3rd: Secretion and metabolism of monomeric human calcitonin: effects of age, sex, and thyroid damage. J Bone Miner Res. 1986 Aug;1(4):339-49. doi: 10.1002/jbmr.5650010407.
2 Colonic absorption of human calcitonin in man. Clin Sci (Lond). 1992 Nov;83(5):627-31.
3 Abdul Razak AR, Mau-Soerensen M, Gabrail NY, Gerecitano JF, Shields AF, Unger TJ, Saint-Martin JR, Carlson R, Landesman Y, McCauley D, Rashal T, Lassen U, Kim R, Stayner LA, Mirza MR, Kauffman M, Shacham S, Mahipal A: First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors. J Clin Oncol. 2016 Dec;34(34):4142-4150. doi: 10.1200/JCO.2015.65.3949. Epub 2016 Oct 31.
4 Renal metabolism of calcitonin. Am J Physiol. 1988 Apr;254(4 Pt 2):F593-600.