General Information of Drug (ID: DM187UQ)

Drug Name
2-(2-cycloheptylidenehydrazinyl)-4-phenylthiazole
Synonyms
CHEMBL248050; 2-(2-cycloheptylidenehydrazinyl)-4-phenylthiazole; AC1NRV52; BDBM50326635; Cycloheptanone, (4-phenyl-2-thiazolyl)hydrazone; N-(cycloheptylideneamino)-4-phenyl-thiazol-2-amine; 1-cycloheptylidene-2-(4-phenylthiazol-2-yl)hydrazine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 285.4
Logarithm of the Partition Coefficient (xlogp) 4.7
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C16H19N3S
IUPAC Name
N-(cycloheptylideneamino)-4-phenyl-1,3-thiazol-2-amine
Canonical SMILES
C1CCCC(=NNC2=NC(=CS2)C3=CC=CC=C3)CC1
InChI
InChI=1S/C16H19N3S/c1-2-7-11-14(10-6-1)18-19-16-17-15(12-20-16)13-8-4-3-5-9-13/h3-5,8-9,12H,1-2,6-7,10-11H2,(H,17,19)
InChIKey
HFWROKPXAPGNOY-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5273551
TTD ID
D0Q1IP

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Monoamine oxidase type A (MAO-A) TT3WG5C AOFA_HUMAN Inhibitor [1]
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Monoamine oxidase type B (MAO-B) DTT MAOB 2.65E-02 1.12E-02 0.07
Monoamine oxidase type A (MAO-A) DTT MAOA 8.14E-01 0.05 0.1
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70.