Details of Disease

General Information of Disease (ID: DIS0VQYF)

• Disease Name: Iron-deficiency anemia
• Synonyms: iron-deficiency anemia; iron-deficiency anaemia
• Disease Class: 3A00: Iron deficiency anaemia
• Definition: Anemia caused by low iron intake, inefficient iron absorption in the gastrointestinal tract, or chronic blood loss.
• Disease Hierarchy:
  DIS0RMTQ: Hypochromic microcytic anemia
  DISI8W45: Anaemia
  DIS1UUNY: Malnutrition
  DIS0VQYF: Iron-deficiency anemia
• ICD Code:
  ICD-11: ICD-11: 3A00
  ICD-9: ICD-9: 280
  Expand ICD-11: '3A00
  Expand ICD-10: 'D50; 'D50.1; 'D50.8; 'D50.9
  Expand ICD-9: 280
• Disease Identifiers:
  MONDO ID: MONDO_0001356
  UMLS CUI: C0162316
  MedGen ID: 57668
  HPO ID: HP:0001891
  SNOMED CT ID: 87522002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 9 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cyanocobalamin	DMYY0AJ	Approved	NA	[1]
Ferric maltol	DMVYD7I	Approved	NA	[2]
Folic Acid	DMEMBJC	Approved	Small molecular drug	[3]
Iron	DMAP8MV	Approved	Small molecular drug	[4]
Iron Dextran	DM5OY70	Approved	Small molecular drug	[5]
Monofer	DMY1I7R	Approved	NA	[6]
Sodium ferric gluconate complex	DMF699X	Approved	Small molecular drug	[6]
Triferic	DMYKU23	Approved	NA	[7]
VIT-45	DM3RGV5	Approved	NA	[6]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Soluble ferric pyrophosphate	DMLAYTP	Phase 3	Small molecular drug	[8]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ATP4A	TTF1QVM	Limited	Genetic Variation	[9]
CA1	TTHQPL7	Limited	Biomarker	[10]
CACNA2D3	TTN7T29	Limited	Biomarker	[11]
LALBA	TTBRLU3	Limited	Biomarker	[12]
SOD1	TTP9K3Q	Limited	Biomarker	[13]
IDUA	TT0IUKX	Disputed	Biomarker	[14]
FGF23	TT2IZ4K	Strong	Genetic Variation	[15]
HBA2	TTQO71U	Strong	Genetic Variation	[16]
RET	TT4DXQT	Strong	Altered Expression	[17]
SLC11A2	TT2IS7P	Strong	Biomarker	[18]
TMPRSS6	TTL9KE7	Strong	Genetic Variation	[19]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC44A1	DT3I2SU	Limited	Biomarker	[20]
SLC44A2	DTSF91X	Limited	Altered Expression	[20]

This Disease Is Related to 12 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACO1	OT2VUR7L	Limited	Altered Expression	[21]
BPNT1	OTPX5PSQ	Limited	Biomarker	[22]
ERFE	OTSES1HA	Limited	Biomarker	[23]
GADD45GIP1	OT4IZ4TP	Limited	Altered Expression	[24]
HBD	OTRQG4WA	Limited	Genetic Variation	[25]
TFR2	OTMYCCEO	Limited	Genetic Variation	[26]
ACAD8	OT3JI5GB	Disputed	Genetic Variation	[14]
CHMP2B	OTZA7RJB	Strong	Biomarker	[18]
DMRT1	OT5PU9U1	Strong	Biomarker	[18]
HBA1	OTW2BQF4	Strong	Genetic Variation	[16]
IREB2	OT747D24	Strong	Genetic Variation	[27]
HFE	OTDD93KB	Definitive	Biomarker	[19]

References

• [1] Cyanocobalamin FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [3] Folic acid FDA Label
• [4] Drug information of Iron, 2008. eduDrugs.
• [5] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010787.
• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [7] Clinical pipeline report, company report or official report of Rockwell medical technologies.
• [8] Clinical pipeline report, company report or official report of Rockwell Medical Inc.
• [9] Iron Deficiency Anemia Associated With Acid-Modifying Medications: Two Cases and Literature Review.Am J Med Sci. 2019 Feb;357(2):160-163. doi: 10.1016/j.amjms.2018.10.014. Epub 2018 Nov 1.
• [10] Anti-carbonic anhydrase antibodies in iron deficiency anemia.Hematology. 2015 Jul;20(6):363-7. doi: 10.1179/1607845414Y.0000000204. Epub 2014 Oct 6.
• [11] Genetic contribution to iron status: SNPs related to iron deficiency anaemia and fine mapping of CACNA2D3 calcium channel subunit.Blood Cells Mol Dis. 2015 Dec;55(4):273-80. doi: 10.1016/j.bcmd.2015.07.008. Epub 2015 Jul 16.
• [12] Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial.Eur Rev Med Pharmacol Sci. 2018 Jun;22(11):3602-3608. doi: 10.26355/eurrev_201806_15187.
• [13] Erythrocyte CuZn superoxide dismutase activity is decreased in iron-deficiency anemia.Biol Trace Elem Res. 2006 Sep;112(3):213-20. doi: 10.1385/BTER:112:3:213.
• [14] Inflammation, but Not the Underlying Disease or Its Location, Predicts Oral Iron Absorption Capacity in Patients With Inflammatory Bowel Disease.J Crohns Colitis. 2020 Mar 13;14(3):316-322. doi: 10.1093/ecco-jcc/jjz149.
• [15] Effect of ferric citrate on serum phosphate and fibroblast growth factor 23 among patients with nondialysis-dependent chronic kidney disease: path analyses.Nephrol Dial Transplant. 2019 Jul 1;34(7):1115-1124. doi: 10.1093/ndt/gfy318.
• [16] Hematological phenotypes in children according to the -globin genotypes.Blood Cells Mol Dis. 2018 Mar;69:102-106. doi: 10.1016/j.bcmd.2017.10.003. Epub 2017 Nov 3.
• [17] The Importance of RET-He in the Diagnosis of Iron Deficiency and Iron Deficiency Anemia and the Evaluation of Response to Oral Iron Therapy.J Med Biochem. 2019 Jan 22;38(4):496-502. doi: 10.2478/jomb-2018-0052. eCollection 2019 Oct.
• [18] Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis.Mol Ther. 2019 Mar 6;27(3):493-506. doi: 10.1016/j.ymthe.2019.01.003. Epub 2019 Jan 12.
• [19] The role of TMPRSS6 and HFE variants in iron deficiency anemia in celiac disease.Am J Hematol. 2018 Mar;93(3):383-393. doi: 10.1002/ajh.24991. Epub 2017 Dec 18.
• [20] Iron therapy substantially restores qEEG maturational lag among iron-deficient anemic infants.Nutr Neurosci. 2019 May;22(5):363-372. doi: 10.1080/1028415X.2017.1391529. Epub 2017 Oct 24.
• [21] Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.Haematologica. 2006 Mar;91(3):303-10. Epub 2006 Feb 17.
• [22] Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis.Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3000-3005. doi: 10.1073/pnas.1715302115. Epub 2018 Mar 5.
• [23] Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia.Eur J Haematol. 2018 Apr;100(4):356-360. doi: 10.1111/ejh.13021. Epub 2018 Feb 7.
• [24] CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells.PLoS One. 2014 Feb 10;9(2):e85328. doi: 10.1371/journal.pone.0085328. eCollection 2014.
• [25] First report of the spectrum of -globin gene mutations in Omani subjects - identification of novel mutations.Int J Lab Hematol. 2015 Apr;37(2):238-43. doi: 10.1111/ijlh.12272. Epub 2014 Jul 9.
• [26] TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia.Hum Mol Genet. 2012 May 1;21(9):2124-31. doi: 10.1093/hmg/dds028. Epub 2012 Feb 8.
• [27] Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome.Brain. 2019 May 1;142(5):1195-1202. doi: 10.1093/brain/awz072.