Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTHEBX9R)

• DOT Name: Catalase (CAT)
• Synonyms: EC 1.11.1.6
• Gene Name: CAT
• Related Disease: Acatalasia
• UniProt ID: CATA_HUMAN
• PDB ID: 1DGB; 1DGF; 1DGG; 1DGH; 1F4J; 1QQW; 7P8W; 7VD9; 8EL9; 8HID; 8PVD
• EC Number: 1.11.1.6
• Pfam ID: PF00199 ; PF06628
• Sequence:
  MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
  MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
  GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
  MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
  GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
  KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
  THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
  HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
  NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL
• Function: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
• KEGG Pathway:
  Tryptophan metabolism (hsa00380)
  Glyoxylate and dicarboxylate metabolism (hsa00630)
  Metabolic pathways (hsa01100)
  Carbon metabolism (hsa01200)
  FoxO sig.ling pathway (hsa04068)
  Peroxisome (hsa04146)
  Longevity regulating pathway (hsa04211)
  Longevity regulating pathway - multiple species (hsa04213)
  Amyotrophic lateral sclerosis (hsa05014)
  Pathways of neurodegeneration - multiple diseases (hsa05022)
  Chemical carcinogenesis - reactive oxygen species (hsa05208)
• Reactome Pathway:
  Neutrophil degranulation (R-HSA-6798695)
  Peroxisomal protein import (R-HSA-9033241)
  FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (R-HSA-9615017)
  Detoxification of Reactive Oxygen Species (R-HSA-3299685)
• BioCyc Pathway: MetaCyc:MONOMER66-341

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Acatalasia	DISWKSHU	Strong	Autosomal recessive	[1]

This DOT Affected the Drug Response of 18 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Cisplatin	DMRHGI9	Approved	Catalase (CAT) decreases the response to substance of Cisplatin.	[92]
Arsenic	DMTL2Y1	Approved	Catalase (CAT) increases the response to substance of Arsenic.	[93]
Menadione	DMSJDTY	Approved	Catalase (CAT) decreases the response to substance of Menadione.	[94]
Hydroquinone	DM6AVR4	Approved	Catalase (CAT) decreases the response to substance of Hydroquinone.	[95]
Ethanol	DMDRQZU	Approved	Catalase (CAT) decreases the response to substance of Ethanol.	[96]
Paclitaxel	DMLB81S	Approved	Catalase (CAT) increases the response to substance of Paclitaxel.	[97]
Vinblastine	DM5TVS3	Approved	Catalase (CAT) affects the response to substance of Vinblastine.	[98]
Daunorubicin	DMQUSBT	Approved	Catalase (CAT) affects the response to substance of Daunorubicin.	[99]
Haloperidol	DM96SE0	Approved	Catalase (CAT) increases the Orofacial dyskinesia ADR of Haloperidol.	[100]
Phenytoin	DMNOKBV	Approved	Catalase (CAT) decreases the response to substance of Phenytoin.	[101]
Tacrolimus	DMZ7XNQ	Approved	Catalase (CAT) decreases the response to substance of Tacrolimus.	[103]
Epinephrine	DM3KJBC	Approved	Catalase (CAT) decreases the response to substance of Epinephrine.	[104]
Osimertinib	DMRJLAT	Approved	Catalase (CAT) decreases the response to substance of Osimertinib.	[105]
Dicumarol	DMFQCB1	Approved	Catalase (CAT) decreases the response to substance of Dicumarol.	[106]
Nickel chloride	DMI12Y8	Investigative	Catalase (CAT) decreases the response to substance of Nickel chloride.	[107]
Benzoquinone	DMNBA0G	Investigative	Catalase (CAT) decreases the response to substance of Benzoquinone.	[95]
PATULIN	DM0RV9C	Investigative	Catalase (CAT) decreases the response to substance of PATULIN.	[108]
Misonidazole	DMYB0HK	Investigative	Catalase (CAT) affects the response to substance of Misonidazole.	[110]

This DOT Affected the Regulation of Drug Effects of 2 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Dinoprostone	DMTYOPD	Approved	Catalase (CAT) decreases the abundance of Dinoprostone.	[102]
Metanephrine	DMTGMB1	Investigative	Catalase (CAT) increases the abundance of Metanephrine.	[109]

98 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Ciclosporin	DMAZJFX	Approved	Ciclosporin decreases the expression of Catalase (CAT).	[2]
Tretinoin	DM49DUI	Approved	Tretinoin increases the expression of Catalase (CAT).	[3]
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Catalase (CAT).	[4]
Doxorubicin	DMVP5YE	Approved	Doxorubicin increases the expression of Catalase (CAT).	[5]
Cupric Sulfate	DMP0NFQ	Approved	Cupric Sulfate decreases the expression of Catalase (CAT).	[6]
Estradiol	DMUNTE3	Approved	Estradiol increases the expression of Catalase (CAT).	[7]
Ivermectin	DMDBX5F	Approved	Ivermectin decreases the expression of Catalase (CAT).	[8]
Quercetin	DM3NC4M	Approved	Quercetin decreases the expression of Catalase (CAT).	[9]
Arsenic trioxide	DM61TA4	Approved	Arsenic trioxide decreases the expression of Catalase (CAT).	[10]
Hydrogen peroxide	DM1NG5W	Approved	Hydrogen peroxide decreases the expression of Catalase (CAT).	[11]
Triclosan	DMZUR4N	Approved	Triclosan affects the expression of Catalase (CAT).	[12]
Methotrexate	DM2TEOL	Approved	Methotrexate increases the expression of Catalase (CAT).	[13]
Marinol	DM70IK5	Approved	Marinol decreases the expression of Catalase (CAT).	[14]
Selenium	DM25CGV	Approved	Selenium increases the activity of Catalase (CAT).	[15]
Phenobarbital	DMXZOCG	Approved	Phenobarbital decreases the expression of Catalase (CAT).	[16]
Fluorouracil	DMUM7HZ	Approved	Fluorouracil decreases the activity of Catalase (CAT).	[17]
Dexamethasone	DMMWZET	Approved	Dexamethasone increases the expression of Catalase (CAT).	[18]
Cannabidiol	DM0659E	Approved	Cannabidiol decreases the activity of Catalase (CAT).	[17]
Troglitazone	DM3VFPD	Approved	Troglitazone increases the expression of Catalase (CAT).	[19]
Rosiglitazone	DMILWZR	Approved	Rosiglitazone increases the expression of Catalase (CAT).	[19]
Etoposide	DMNH3PG	Approved	Etoposide increases the activity of Catalase (CAT).	[20]
Malathion	DMXZ84M	Approved	Malathion decreases the activity of Catalase (CAT).	[21]
Simvastatin	DM30SGU	Approved	Simvastatin increases the activity of Catalase (CAT).	[23]
Topotecan	DMP6G8T	Approved	Topotecan increases the expression of Catalase (CAT).	[24]
Melphalan	DMOLNHF	Approved	Melphalan decreases the activity of Catalase (CAT).	[25]
Methamphetamine	DMPM4SK	Approved	Methamphetamine decreases the expression of Catalase (CAT).	[26]
Lindane	DMB8CNL	Approved	Lindane increases the activity of Catalase (CAT).	[27]
Vitamin C	DMXJ7O8	Approved	Vitamin C increases the expression of Catalase (CAT).	[28]
Nefazodone	DM4ZS8M	Approved	Nefazodone decreases the expression of Catalase (CAT).	[29]
Dihydroartemisinin	DMBXVMZ	Approved	Dihydroartemisinin increases the expression of Catalase (CAT).	[30]
Bosentan	DMIOGBU	Approved	Bosentan decreases the expression of Catalase (CAT).	[31]
Ardeparin	DMYRX8B	Approved	Ardeparin increases the activity of Catalase (CAT).	[32]
Adenosine triphosphate	DM79F6G	Approved	Adenosine triphosphate increases the expression of Catalase (CAT).	[33]
Propofol	DMB4OLE	Approved	Propofol decreases the activity of Catalase (CAT).	[34]
Artesunate	DMR27C8	Approved	Artesunate increases the expression of Catalase (CAT).	[35]
Isoniazid	DM5JVS3	Approved	Isoniazid decreases the activity of Catalase (CAT).	[36]
Orlistat	DMRJSP8	Approved	Orlistat decreases the expression of Catalase (CAT).	[37]
Atazanavir	DMSYRBX	Approved	Atazanavir decreases the expression of Catalase (CAT).	[29]
Penicillamine	DM40EF6	Approved	Penicillamine decreases the expression of Catalase (CAT).	[38]
Bleomycin	DMNER5S	Approved	Bleomycin increases the expression of Catalase (CAT).	[39]
Methimazole	DM25FL8	Approved	Methimazole decreases the expression of Catalase (CAT).	[40]
Hesperetin	DMKER83	Approved	Hesperetin decreases the activity of Catalase (CAT).	[41]
Benzoic acid	DMKB9FI	Approved	Benzoic acid decreases the activity of Catalase (CAT).	[42]
Clomipramine	DMINRKW	Approved	Clomipramine decreases the expression of Catalase (CAT).	[40]
Citalopram	DM2G9AE	Approved	Citalopram decreases the expression of Catalase (CAT).	[43]
Gallium nitrate	DMF9O6B	Approved	Gallium nitrate decreases the expression of Catalase (CAT).	[44]
Amphetamine	DMSZQAK	Approved	Amphetamine decreases the activity of Catalase (CAT).	[45]
Aluminium	DM6ECN9	Approved	Aluminium decreases the activity of Catalase (CAT).	[46]
Chloramphenicol	DMFXEWT	Approved	Chloramphenicol increases the expression of Catalase (CAT).	[47]
Amikacin	DM5PDRB	Approved	Amikacin decreases the activity of Catalase (CAT).	[48]
Oxytetracycline	DMOVH1M	Approved	Oxytetracycline decreases the activity of Catalase (CAT).	[49]
Piperazine	DMTY9LU	Approved	Piperazine increases the activity of Catalase (CAT).	[50]
Iron Dextran	DM5OY70	Approved	Iron Dextran decreases the activity of Catalase (CAT).	[51]
Aprindine	DMBXWU8	Approved	Aprindine decreases the expression of Catalase (CAT).	[40]
Beclomethasone dipropionate	DM5NW1E	Phase 4	Beclomethasone dipropionate increases the expression of Catalase (CAT).	[52]
Silymarin	DMXBYQR	Phase 4	Silymarin increases the activity of Catalase (CAT).	[53]
Resveratrol	DM3RWXL	Phase 3	Resveratrol increases the expression of Catalase (CAT).	[54]
Epigallocatechin gallate	DMCGWBJ	Phase 3	Epigallocatechin gallate increases the activity of Catalase (CAT).	[55]
Chlorpromazine	DMBGZI3	Phase 3 Trial	Chlorpromazine decreases the expression of Catalase (CAT).	[56]
Atorvastatin	DMF28YC	Phase 3 Trial	Atorvastatin increases the activity of Catalase (CAT).	[23]
Crocin	DM5F24X	Phase 3	Crocin decreases the activity of Catalase (CAT).	[57]
Genistein	DM0JETC	Phase 2/3	Genistein increases the expression of Catalase (CAT).	[58]
Amiodarone	DMUTEX3	Phase 2/3 Trial	Amiodarone decreases the expression of Catalase (CAT).	[59]
Tocopherol	DMBIJZ6	Phase 2	Tocopherol increases the expression of Catalase (CAT).	[60]
DNCB	DMDTVYC	Phase 2	DNCB increases the expression of Catalase (CAT).	[61]
Disulfiram	DMCL2OK	Phase 2 Trial	Disulfiram decreases the expression of Catalase (CAT).	[62]
Delphinidin	DMS2WIN	Phase 2	Delphinidin decreases the activity of Catalase (CAT).	[63]
PIPERINE	DMYEAB1	Phase 1/2	PIPERINE decreases the expression of Catalase (CAT).	[64]
Leflunomide	DMR8ONJ	Phase 1 Trial	Leflunomide decreases the expression of Catalase (CAT).	[66]
Aminoguanidine	DMJQDUC	Phase 1	Aminoguanidine decreases the expression of Catalase (CAT).	[67]
Eugenol	DM7US1H	Patented	Eugenol increases the expression of Catalase (CAT).	[61]
PMID26394986-Compound-22	DM43Z1G	Patented	PMID26394986-Compound-22 decreases the expression of Catalase (CAT).	[68]
Flavonoid derivative 1	DMCQP0B	Patented	Flavonoid derivative 1 affects the activity of Catalase (CAT).	[69]
PMID26560530-Compound-25	DMZ43OM	Patented	PMID26560530-Compound-25 increases the activity of Catalase (CAT).	[70]
3,4-Dihydroxybenzaldehyde	DM4O3DW	Patented	3,4-Dihydroxybenzaldehyde increases the activity of Catalase (CAT).	[71]
Tetramethylpyrazine	DMC0WNB	Discontinued in Phase 2	Tetramethylpyrazine increases the activity of Catalase (CAT).	[72]
PIRINIXIC ACID	DM82Y75	Preclinical	PIRINIXIC ACID decreases the activity of Catalase (CAT).	[73]
Citrate	DM37NYK	Preclinical	Citrate decreases the activity of Catalase (CAT).	[42]
HSDB-41	DMR8VJA	Preclinical	HSDB-41 decreases the activity of Catalase (CAT).	[74]
Trimidox	DMY8GDA	Preclinical	Trimidox increases the expression of Catalase (CAT).	[75]
Nimesulide	DMR1NMD	Terminated	Nimesulide decreases the expression of Catalase (CAT).	[68]
NS398	DMINUWH	Terminated	NS398 decreases the expression of Catalase (CAT).	[68]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the expression of Catalase (CAT).	[76]
Formaldehyde	DM7Q6M0	Investigative	Formaldehyde decreases the activity of Catalase (CAT).	[77]
Milchsaure	DM462BT	Investigative	Milchsaure decreases the expression of Catalase (CAT).	[78]
Coumarin	DM0N8ZM	Investigative	Coumarin decreases the activity of Catalase (CAT).	[79]
Acetaldehyde	DMJFKG4	Investigative	Acetaldehyde decreases the activity of Catalase (CAT).	[80]
3R14S-OCHRATOXIN A	DM2KEW6	Investigative	3R14S-OCHRATOXIN A increases the expression of Catalase (CAT).	[81]
methyl p-hydroxybenzoate	DMO58UW	Investigative	methyl p-hydroxybenzoate increases the expression of Catalase (CAT).	[82]
Paraquat	DMR8O3X	Investigative	Paraquat decreases the expression of Catalase (CAT).	[83]
Glyphosate	DM0AFY7	Investigative	Glyphosate increases the expression of Catalase (CAT).	[84]
D-glucose	DMMG2TO	Investigative	D-glucose increases the expression of Catalase (CAT).	[85]
geraniol	DMS3CBD	Investigative	geraniol decreases the activity of Catalase (CAT).	[86]
Phencyclidine	DMQBEYX	Investigative	Phencyclidine decreases the expression of Catalase (CAT).	[87]
Okadaic acid	DM47CO1	Investigative	Okadaic acid decreases the expression of Catalase (CAT).	[88]
Chlorpyrifos	DMKPUI6	Investigative	Chlorpyrifos increases the activity of Catalase (CAT).	[89]
CH-223191	DMMJZYC	Investigative	CH-223191 decreases the expression of Catalase (CAT).	[90]
Bilirubin	DMI0V4O	Investigative	Bilirubin decreases the expression of Catalase (CAT).	[91]

1 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Permethrin	DMZ0Q1G	Approved	Permethrin affects the binding of Catalase (CAT).	[22]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of Catalase (CAT).	[65]

References

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