Details of the Drug

General Information of Drug (ID: DMC013U)

• Drug Name: 6-Thiophen-2-yl-imidazo[2,1-b]thiazole
• Synonyms: 6-(thiophen-2-yl)imidazo[2,1-b][1,3]thiazole; AC1Q7FWK; AC1N51XV; CHEMBL12113; IFLab2_000013; IFLab1_003798; MolPort-000-476-548; HMS1422M14; ZINC406855; STL115074; CCG-22586; AKOS002232733; MCULE-2716534216; 6-(2-Thienyl)imidazo[2,1-b]thiazole; IDI1_019039; IDI1_009905; imidazo[2,1-b]thiazole,6-(2-thienyl)-; KB-305118; EU-0080970; ST50113084; 6-(2-thienyl)imidazo[2,1-b]1,3-thiazoline; 6-thiophen-2-ylimidazo[2,1-b][1,3]thiazole; SR-01000506671

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 206.3
  Logarithm of the Partition Coefficient (xlogp); 3.2
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 0
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C9H6N2S2
  IUPAC Name: 6-thiophen-2-ylimidazo[2,1-b][1,3]thiazole
  Canonical SMILES: C1=CSC(=C1)C2=CN3C=CSC3=N2
  InChI: InChI=1S/C9H6N2S2/c1-2-8(12-4-1)7-6-11-3-5-13-9(11)10-7/h1-6H
  InChIKey: YKINBJCTANWRJC-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 4164759
  TTD ID: D0J3TS

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
NADH dehydrogenase (MT-ND3)	TTTJF7V	NU3M_HUMAN	Inhibitor	[1]

References

• [1] Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase. J Med Chem. 1995 Mar 31;38(7):1090-7.