Details of the Drug

General Information of Drug (ID: DMCG7XL)

Drug Name

AMG 910

Indication

Disease Entry	ICD 11	Status	REF
Esophagogastric junction neoplasm	2B71	Phase 1	[1]
Gastric adenocarcinoma	2B72	Phase 1	[1]
------------------------------------------------------------------------------------

Drug Type

Antibody

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Claudin-18 (CLDN18)	TT6PKBX	CLD18_HUMAN	Inhibitor	[2]
T-cell surface glycoprotein CD3 (CD3)	TTUN7MC	NOUNIPROTAC	Inhibitor	[2]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT04260191) Study of AMG 910 in Subjects With CLDN18.2-Positive Gastric and Gastroesophageal Junction Adenocarcinoma. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Amgen.