Details of the Drug

General Information of Drug (ID: DMCGATN)

Drug Name

Apabetalone

Synonyms

RVX 000222; 1044870-39-4; 2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one; RVX-000222; 2-[4-(2-Hydroxyethoxy)-3,5-Dimethylphenyl]-5,7-Dimethoxyquinazolin-4(3h)-One; UNII-8R4A7GDZ1D; RVX 000222; 8R4A7GDZ1D; QC-216; AK110565; Apabetalone [INN]; RVX000222; Apabetalone [USAN:INN]; 1K0; 4mr4; 4mr6; 4j1p; 4j3i; Apabetalone (USAN/INN); D0N7WW; SCHEMBL145019; GTPL7034; SCHEMBL17002023; AOB2133; DTXSID90146502; MolPort-027-835-445; NETXMUIMUZJUTB-UHFFFAOYSA-N; HMS3653C10; EX-A1110; BCP07787; ZINC4319

Indication

Disease Entry	ICD 11	Status	REF
Cardiac events	MC82	Phase 3	[1]
Cardiovascular disease	BA00-BE2Z	Phase 3	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
------------------------------------------------------------------------------------

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C20H22N2O5
Canonical SMILES: CC1=CC(=CC(=C1OCCO)C)C2=NC3=C(C(=CC(=C3)OC)OC)C(=O)N2
InChI: 1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-14(25-3)10-16(26-4)17(15)20(24)22-19/h7-10,23H,5-6H2,1-4H3,(H,21,22,24)
InChIKey: NETXMUIMUZJUTB-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 135564749
CAS Number: 1044870-39-4
TTD ID: D0F1JD

Combinatorial Drugs (CBD)

Click to Jump to the Detailed CBD Information of This Drug

Repurposed Drugs (RPD)

Click to Jump to the Detailed RPD Information of This Drug

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Nat Rev Drug Discov. 2016 Aug;15(8):533-50.
3	Resverlogix Clinical Candidate Apabetalone Featured as a Potential COVID-19 Treatment in Recent PublicationEpigenetic BET-inhibition to combat COVID-19. Mar 24, 2020.