General Information of Drug (ID: DMD9FZW)

Drug Name
4-butylphenylboronic acid
Synonyms
4-Butylphenylboronic acid; 145240-28-4; (4-butylphenyl)boronic Acid; 4-n-Butylphenylboronic acid; 4-Butylphenylboronicacid; 4-Butylbenzeneboronic Acid; 4-N-BUTYLBENZENEBORONIC ACID; (4-Butylphenyl)Boranediol; CHEMBL555064; Boronic acid, (4-butylphenyl)-; MFCD02093926; AK-47631; 4-n-Butylphenylboronic acid, 95%; Boronic acid, B-(4-butylphenyl)-; PubChem18523; ACMC-209cue; AC1N2RDA; 4-Butylphenylboranic acid; 4-n-Butylphenylboronicacid; 4-butylphenyl boronic acid; 4-butyl-phenylboronic acid; AC1Q2VE3; 4-butyl phenyl boronic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
0
Molecular Weight 178.04
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 4
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 2
Chemical Identifiers
Formula
C10H15BO2
IUPAC Name
(4-butylphenyl)boronic acid
Canonical SMILES
B(C1=CC=C(C=C1)CCCC)(O)O
InChI
InChI=1S/C10H15BO2/c1-2-3-4-9-5-7-10(8-6-9)11(12)13/h5-8,12-13H,2-4H2,1H3
InChIKey
UGZUUTHZEATQAM-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4100860
CAS Number
145240-28-4
TTD ID
D05NFU

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5.