General Information of Drug (ID: DMF16CU)

Drug Name
Vicasinabin
Synonyms
Vicasinabin; Vicasinabin [INN]; QJ8UO6C05M; RG7774; 1433361-02-4; RG-7774; (S)-1-(5-tert-Butyl-3-((1-methyl-1H-tetrazol-5-yl)methyl)-3H-(1,2,3)triazolo-(4,5-d)pyrimidin-7-yl)pyrrolidin-3-ol; 3-Pyrrolidinol, 1-(5-(1,1-dimethylethyl)-3-((1-methyl-1H-tetrazol-5-yl)methyl)-3H-1,2,3-triazolo(4,5-d)pyrimidin-7-yl)-, (3S)-; 3-Pyrrolidinol, 1-[5-(1,1-dimethylethyl)-3-[(1-methyl-1H-tetrazol-5-yl)methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-yl]-, (3S)-; VICASINABIN [USAN]; UNII-QJ8UO6C05M; SCHEMBL14912040; GTPL11890; EX-A8231; AKOS040756804; Example 151 [WO2013068306A1]; HY-145604; RO6868847; CS-0376695; RO-6868847; (3S)-1-(5-(1,1-Dimethylethyl)-3-((1-methyl-1H-tetrazol-5-yl)methyl)-3H-1,2,3-triazolo(4,5-d)pyrimidin-7-yl)-3-pyrrolidinol; (3S)-1-[5-tert-butyl-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol; (3S)-1-{5-tert-butyl-3-[(1-methyl-1H-tetrazol-5-yl)methyl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl{pyrrolidin-3-ol
Indication
Disease Entry ICD 11 Status REF
Diabetic retinopathy 9B71.0 Phase 2 [1]
Drug Type
Small molecule
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C15H22N10O
Canonical SMILES
CC(C)(C)C1=NC2=C(C(=N1)N3CCC(C3)O)N=NN2CC4=NN=NN4C
InChI
InChI=1S/C15H22N10O/c1-15(2,3)14-16-12(24-6-5-9(26)7-24)11-13(17-14)25(21-19-11)8-10-18-20-22-23(10)4/h9,26H,5-8H2,1-4H3/t9-/m0/s1
InChIKey
MAYZWDRUFKUGGP-VIFPVBQESA-N
Cross-matching ID
PubChem CID
86296048
TTD ID
DMJ2N9

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cannabinoid receptor 2 (CB2) TTMSFAW CNR2_HUMAN Agonist [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Diabetic retinopathy
ICD Disease Classification 9B71.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cannabinoid receptor 2 (CB2) DTT CNR2 3.82E-02 -0.43 -1.18
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of Roche