Details of the Drug

General Information of Drug (ID: DMGIN7J)

Drug Name

Onyvax-105

Synonyms

Antibody therapy (colerectal cancer), CRC/Onyvax; Vaccine (colorectal cancer), CRC/ImClone; Vaccine (colorectal cancer), CRC/Onyvax

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 1/2	[1]
Colorectal cancer	2B91.Z	Discontinued in Phase 1	[2]
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Drug Type

Vaccine

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Complement decay-accelerating factor (CD55)	TT5Z9WY	DAF_HUMAN	Not Available	[3]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Prostate cancer

ICD Disease Classification

2C82.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Complement decay-accelerating factor (CD55)	DTT	CD55	2.44E-02	2.16	3.38

Molecular Expression Atlas (MEA)

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References

1	Onyvax-105 Cancer Vaccine Shows Encouraging Clinical Results in Osteosarcoma Patients After Intensive Chemotherapy. Onyvax vaccines therapies. April 19, 2005.
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006889)
3	Technology evaluation: Onyvax-105, Onyvax. Curr Opin Mol Ther. 2003 Dec;5(6):668-72.