Details of the Drug

General Information of Drug (ID: DMH4AGL)

• Drug Name: Tetraethylene Glycol
• Synonyms: TETRAETHYLENE GLYCOL; 112-60-7; Tetraglycol; 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol; HI-Dry; Carbitol, diethyl; 3,6,9-Trioxaundecane-1,11-diol; Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-; Tetra(ethylene glycol); NSC 1262; 2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol; Bis[2-(2-hydroxyethoxy)ethyl] ether; HSDB 843; Ethanol, 2,2'-(oxybis(ethyleneoxy))di-; 3,6,9-Trioxaundecan-1,11-diol; EINECS 203-989-9; BRN 1634320; PEG-4; AI3-01838; 2,2'-[oxybis(2,1-ethanediyloxy)]diethanol; CHEBI:44920; UWHCKJMYHZGTIT-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 194.23
  Logarithm of the Partition Coefficient (xlogp); -1.6
  Rotatable Bond Count (rotbonds); 10
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C8H18O5
  IUPAC Name: 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol
  Canonical SMILES: C(COCCOCCOCCO)O
  InChI: InChI=1S/C8H18O5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h9-10H,1-8H2
  InChIKey: UWHCKJMYHZGTIT-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 8200
  ChEBI ID: CHEBI:44920
  CAS Number: 112-60-7
  TTD ID: D0D9PI

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Acetylcholinesterase (AChE)	DTT	ACHE	6.39E-02	-1.07	-1.15

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.