Details of the Drug

General Information of Drug (ID: DMHP71R)

Drug Name
IQ-DAA
Synonyms
Anti-anthrax toxin mAb, IQ; Human monoclonal antibodies (anthrax), IQ; IQN-protective antigen (human mAb), IQ corporation; MAb-based immunotherapy (anthrax), IQ; IQNLF + IQNPA (human mAbs, Bacillus anthracis infection), IQ Therapeutics
Indication
Disease Entry ICD 11 Status REF
Bacillus anthracis infection 1G40 Phase 1 [1]
Cross-matching ID
TTD ID
D09SZY

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Lethal factor (Bact lef) TTIQSC1 LEF_BACAN Modulator [2]
Bacterial Protective antigen (Bact pagA) TT3YGCD PAG_BACAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020942)
2 Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.Future Microbiol.2009 Feb;4(1):35-43.
3 Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43.
4 Phase I Study Evaluating the Safety and Pharmacokinetics of MDX-1303, a Fully Human Monoclonal Antibody against Bacillus anthracis Protective Antigen, in Healthy Volunteers. Clin Vaccine Immunol. 2011 December; 18(12): 2136-2142.
5 Efficacy and Safety of AVP-21D9, an Anthrax Monoclonal Antibody, in Animal Models and Humans. Antimicrob Agents Chemother. 2014 July; 58(7): 3618-3625.
6 Annual Reports in Medicinal Chemistry. Annette M. Doherty. 2005. Page(214).
7 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8 Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11.
9 The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8.
10 Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232-44.
11 Inhibitors of anthrax lethal factor based upon N-oleoyldopamine. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2467-70.
12 Inhibitors of anthrax lethal factor. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8.