Details of the Drug

General Information of Drug (ID: DMJSMDL)

Drug Name

Cefiderocol

Synonyms

Cephalosporin, GSK2696266; S-649266

Indication

Disease Entry	ICD 11	Status	REF
Hospital-acquired pneumonia	CA40.Z	Approved	[1]
Urinary tract infection	GC08	Approved	[1]
Ventilator-associated pneumonia	PK81.0	Approved	[1]
Healthcare-associated pneumonia	CA00-CA40	Phase 3	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C30H34ClN7O10S2
Canonical SMILES: CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4(CCCC4)CCNC(=O)C5=C(C(=C(C=C5)O)O)Cl)C(=O)[O-]
InChI: 1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
InChIKey: DBPPRLRVDVJOCL-FQRUVTKNSA-N

Cross-matching ID

Combinatorial Drugs (CBD)

Repurposed Drugs (RPD)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
2	ClinicalTrials.gov (NCT02714595) Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens (CREDIBLE - CR). U.S. National Institutes of Health.