General Information of Disease (ID: DISMT6UV)

Disease Name Urinary tract infection
Synonyms urinary tract infection (disease)
Disease Class GC08: Urinary tract infection
Disease Hierarchy
DIS0HU8N: Urinary tract disease
DISEM33Q: Infectious disease
DISMT6UV: Urinary tract infection
ICD Code
ICD-11
ICD-11: GC08
ICD-10
ICD-10: N39, N39.0
Disease Identifiers
MONDO ID
MONDO_0100338
UMLS CUI
C0042029
MedGen ID
52943
SNOMED CT ID
68566005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 57 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Acetohydroxamic DM16GO3 Approved NA [1]
Acetohydroxamic Acid DMYX7NI Approved Small molecular drug [2]
Ammonium chloride DMPJCXG Approved Small molecular drug [3]
Amoxicillin DMUYNEI Approved Small molecular drug [4]
Amphotericin B DMTAJQE Approved Small molecular drug [5]
Ampicillin DMHWE7P Approved Small molecular drug [6]
Azlocillin DMIR5QP Approved Small molecular drug [7]
Aztreonam DMDNJHG Approved Small molecular drug [8]
Bacampicillin DMP54C7 Approved Small molecular drug [9]
Carbenicillin DMLEDNK Approved Small molecular drug [10]
Cefaclor DMJXDGC Approved Small molecular drug [11]
Cefadroxil DMMC345 Approved Small molecular drug [12]
Cefalotin DMVYSLE Approved Small molecular drug [13]
Cefamandole DMNEXZF Approved Small molecular drug [14]
Cefiderocol DMJSMDL Approved Small molecular drug [15]
Cefixime DMY60I8 Approved Small molecular drug [16]
Cefmetazole DM42W1B Approved Small molecular drug [17]
Cefonicid DMTX2BH Approved Small molecular drug [18]
Cefradine DMUNSWV Approved Small molecular drug [19]
Ceftezole DMX47U6 Approved Small molecular drug [20]
Ceftizoxime DM3VOGS Approved Small molecular drug [21]
Cephapirin DMV2JNY Approved Small molecular drug [22]
Cinoxacin DM4EWNS Approved Small molecular drug [20]
Clavulanate DM2FGRT Approved Small molecular drug [23]
Cotrimazine DMPEFHD Approved NA [20]
Cyclacillin DMHSJB4 Approved Small molecular drug [24]
Demeclocycline DMZEPFJ Approved Small molecular drug [25]
Doripenem DM9UCJK Approved Small molecular drug [26]
Enoxacin DMYTE6L Approved Small molecular drug [27]
Erythromycin DM4K7GQ Approved Small molecular drug [28]
Finafloxacin DMZEONG Approved Small molecular drug [29]
Fosfomycin DMVGPMX Approved Small molecular drug [30]
Framycetin DMF8DNE Approved Small molecular drug [31]
Fusidic Acid DMWVCF3 Approved Small molecular drug [32]
Kanamycin DM2DMPO Approved Small molecular drug [33]
Lomefloxacin DMVRH9C Approved Small molecular drug [34]
Methenamine DMO794W Approved Small molecular drug [20]
Mezlocillin DMY5JEP Approved Small molecular drug [35]
Minocycline DMVN5OH Approved Small molecular drug [36]
Nalidixic Acid DMRM0JV Approved Small molecular drug [37]
Nitrofurantoin DM7PQIK Approved Small molecular drug [38]
Norfloxacin DMIZ6W2 Approved Small molecular drug [39]
Ofloxacin DM0VQN3 Approved Small molecular drug [40]
Oxytetracycline DMOVH1M Approved Small molecular drug [41]
Piperacillin DMTBKF3 Approved Small molecular drug [42]
Pivmecillinam DMDU0BV Approved Small molecular drug [43]
Plazomicin DMKMBES Approved Small molecular drug [44]
Polymyxin B Sulfate DMN0LP8 Approved Small molecular drug [45]
Prulifloxacin DMOK965 Approved Small molecular drug [46]
Sulfacytine DMKI2XC Approved Small molecular drug [47]
Sulfamethizole DMGCHDS Approved Small molecular drug [48]
Sulfisoxazole DMXLT8C Approved Small molecular drug [20]
Tetracycline DMZA017 Approved Small molecular drug [49]
Ticarcillin DM4ME02 Approved Small molecular drug [50]
Trimethoprim DMM7CHK Approved Small molecular drug [51]
Trovafloxacin DM6AN32 Approved Small molecular drug [52]
Vitamin C DMXJ7O8 Approved Small molecular drug [53]
------------------------------------------------------------------------------------
⏷ Show the Full List of 57 Drug(s)
This Disease is Treated as An Indication in 15 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Enmetazobactam DMZKTYJ Phase 3 Small molecular drug [54]
GSK2140944 DMSMFN2 Phase 3 NA [55]
Sulopenem DMMD856 Phase 3 Small molecular drug [56]
Tebipenem DMVSX6O Phase 3 Small molecular drug [57]
Vaborbactam DMDCFXJ Phase 3 Small molecular drug [58]
Benapenem DMUBTMF Phase 2/3 Small molecular drug [59]
LACTIN-V DMOAPGT Phase 2/3 NA [60]
GSK-2251052 DMLFI7Q Phase 2 Small molecular drug [61]
LYS228 DM23Y6K Phase 2 Small molecular drug [62]
C-1205 DML5P59 Phase 1 Small molecular drug [63]
ETX0282 DMUBD0I Phase 1 Small molecule [64]
GSK3882347 DM1DU20 Phase 1 Small molecule [65]
LBP-EC01 DMKRGIZ Phase 1 NA [66]
RG6319 DMUM6MK Phase 1 NA [67]
UTI vaccine DM0X1SV Phase 1 NA [68]
------------------------------------------------------------------------------------
⏷ Show the Full List of 15 Drug(s)
This Disease is Treated as An Indication in 188 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
Alkyl mannoside derivative 1 DMW57UB Patented Small molecular drug [69]
Alkyl mannoside derivative 10 DMHD51F Patented Carbohydrates [69]
Alkyl mannoside derivative 11 DMMNZ2U Patented Carbohydrates [69]
Alkyl mannoside derivative 12 DMX1OZF Patented Carbohydrates [69]
Alkyl mannoside derivative 2 DMNQUKP Patented Small molecular drug [69]
Alkyl mannoside derivative 3 DML2B58 Patented Carbohydrates [69]
Alkyl mannoside derivative 4 DMZR71O Patented Carbohydrates [69]
Alkyl mannoside derivative 5 DM04ZJ2 Patented Carbohydrates [69]
Alkyl mannoside derivative 6 DMCIV32 Patented Carbohydrates [69]
Alkyl mannoside derivative 7 DMBLSH1 Patented Carbohydrates [69]
Alkyl mannoside derivative 8 DMZP1JT Patented Carbohydrates [69]
Alkyl mannoside derivative 9 DMV1QUX Patented Carbohydrates [69]
Aryl mannoside derivative 1 DM1TV6F Patented Carbohydrates [69]
Aryl mannoside derivative 10 DM251GL Patented Carbohydrates [69]
Aryl mannoside derivative 11 DMRVIPL Patented Carbohydrates [69]
Aryl mannoside derivative 12 DMOG8XT Patented Carbohydrates [69]
Aryl mannoside derivative 13 DM2W7JE Patented Carbohydrates [69]
Aryl mannoside derivative 14 DMR648Z Patented Carbohydrates [69]
Aryl mannoside derivative 15 DMQS8CF Patented Carbohydrates [69]
Aryl mannoside derivative 16 DMP6QEC Patented Carbohydrates [69]
Aryl mannoside derivative 17 DM0FSPQ Patented Carbohydrates [69]
Aryl mannoside derivative 18 DM0YUBR Patented Carbohydrates [69]
Aryl mannoside derivative 19 DM6K29H Patented Carbohydrates [69]
Aryl mannoside derivative 2 DM4S2U5 Patented Carbohydrates [69]
Aryl mannoside derivative 20 DMZ2RV3 Patented Carbohydrates [69]
Aryl mannoside derivative 21 DMJBY68 Patented Carbohydrates [69]
Aryl mannoside derivative 22 DMJFDNB Patented Carbohydrates [69]
Aryl mannoside derivative 23 DMWUNRV Patented Carbohydrates [69]
Aryl mannoside derivative 3 DMF5XU8 Patented Carbohydrates [69]
Aryl mannoside derivative 4 DMO19Y6 Patented Carbohydrates [69]
Aryl mannoside derivative 5 DMMC31R Patented Carbohydrates [69]
Aryl mannoside derivative 6 DM5MIEC Patented Carbohydrates [69]
Aryl mannoside derivative 7 DM9YS40 Patented Carbohydrates [69]
Aryl mannoside derivative 8 DMK6PFQ Patented Carbohydrates [69]
Aryl mannoside derivative 9 DMNSK7U Patented Carbohydrates [69]
Beta-cyclodextrin conjugate derivative 1 DMZKTHL Patented Carbohydrates [69]
Beta-cyclodextrin conjugate derivative 2 DM9W1FO Patented Carbohydrates [69]
Beta-cyclodextrin conjugate derivative 3 DMQJF4P Patented Carbohydrates [69]
Beta-cyclodextrin conjugate derivative 4 DMO9RE8 Patented Carbohydrates [69]
Beta-cyclodextrin conjugate derivative 5 DML2B7G Patented Carbohydrates [69]
Biaryl mannoside derivative 1 DMX6YGS Patented Carbohydrates [69]
Biaryl mannoside derivative 10 DMPF37N Patented Carbohydrates [69]
Biaryl mannoside derivative 11 DMKES0G Patented Carbohydrates [69]
Biaryl mannoside derivative 12 DM5T29W Patented Carbohydrates [69]
Biaryl mannoside derivative 13 DM1Y8OM Patented Carbohydrates [69]
Biaryl mannoside derivative 14 DM4C5QY Patented Carbohydrates [69]
Biaryl mannoside derivative 15 DMKXT7H Patented Carbohydrates [69]
Biaryl mannoside derivative 16 DMP9742 Patented Carbohydrates [69]
Biaryl mannoside derivative 17 DMIXV6G Patented Carbohydrates [69]
Biaryl mannoside derivative 18 DMHOPE0 Patented Carbohydrates [69]
Biaryl mannoside derivative 19 DME8DQ0 Patented Carbohydrates [69]
Biaryl mannoside derivative 2 DMMB60X Patented Carbohydrates [69]
Biaryl mannoside derivative 20 DMNC5S0 Patented Carbohydrates [69]
Biaryl mannoside derivative 21 DMGSLHN Patented Carbohydrates [69]
Biaryl mannoside derivative 22 DMYLVB3 Patented Carbohydrates [69]
Biaryl mannoside derivative 23 DM2YVGH Patented Carbohydrates [69]
Biaryl mannoside derivative 24 DMF5TB4 Patented Carbohydrates [69]
Biaryl mannoside derivative 25 DMRM3E9 Patented Carbohydrates [69]
Biaryl mannoside derivative 26 DMYXLCJ Patented Carbohydrates [69]
Biaryl mannoside derivative 27 DMTDPHY Patented Carbohydrates [69]
Biaryl mannoside derivative 28 DMSNMZ2 Patented Carbohydrates [69]
Biaryl mannoside derivative 29 DMCLTY3 Patented Carbohydrates [69]
Biaryl mannoside derivative 3 DMAITK3 Patented Carbohydrates [69]
Biaryl mannoside derivative 30 DMPLAWQ Patented Carbohydrates [69]
Biaryl mannoside derivative 31 DMMPJ3E Patented Carbohydrates [69]
Biaryl mannoside derivative 4 DMVF63N Patented Carbohydrates [69]
Biaryl mannoside derivative 5 DMRS1WG Patented Carbohydrates [69]
Biaryl mannoside derivative 6 DMEWA7U Patented Carbohydrates [69]
Biaryl mannoside derivative 7 DMD7053 Patented Carbohydrates [69]
Biaryl mannoside derivative 8 DMWF2VG Patented Carbohydrates [69]
Biaryl mannoside derivative 9 DM1Q7AL Patented Carbohydrates [69]
Biphenyl mannoside derivative 1 DMS5UFX Patented Carbohydrates [69]
Biphenyl mannoside derivative 10 DMITLPW Patented Carbohydrates [69]
Biphenyl mannoside derivative 11 DMZF5XI Patented Carbohydrates [69]
Biphenyl mannoside derivative 12 DMU0YST Patented Carbohydrates [69]
Biphenyl mannoside derivative 13 DM83LTH Patented Carbohydrates [69]
Biphenyl mannoside derivative 14 DMMRTWG Patented Carbohydrates [69]
Biphenyl mannoside derivative 15 DM97BIQ Patented Carbohydrates [69]
Biphenyl mannoside derivative 16 DMECZVG Patented Carbohydrates [69]
Biphenyl mannoside derivative 17 DM7L8T5 Patented Carbohydrates [69]
Biphenyl mannoside derivative 18 DM2GZ5Y Patented Carbohydrates [69]
Biphenyl mannoside derivative 19 DMGA0R6 Patented Carbohydrates [69]
Biphenyl mannoside derivative 2 DMQB4DR Patented Carbohydrates [69]
Biphenyl mannoside derivative 20 DMDIYJ1 Patented Carbohydrates [69]
Biphenyl mannoside derivative 21 DMTR6BX Patented Carbohydrates [69]
Biphenyl mannoside derivative 22 DMQGFKY Patented Carbohydrates [69]
Biphenyl mannoside derivative 23 DMC8OVU Patented Carbohydrates [69]
Biphenyl mannoside derivative 24 DMLUZ3K Patented Carbohydrates [69]
Biphenyl mannoside derivative 25 DMBWQ8L Patented Carbohydrates [69]
Biphenyl mannoside derivative 26 DM5Q4T2 Patented Carbohydrates [69]
Biphenyl mannoside derivative 27 DMWQ6FJ Patented Carbohydrates [69]
Biphenyl mannoside derivative 28 DMMOTWK Patented Carbohydrates [69]
Biphenyl mannoside derivative 29 DM9H0Q3 Patented Carbohydrates [69]
Biphenyl mannoside derivative 3 DMOKJEP Patented Carbohydrates [69]
Biphenyl mannoside derivative 30 DM81RIY Patented Carbohydrates [69]
Biphenyl mannoside derivative 4 DM0VR23 Patented Carbohydrates [69]
Biphenyl mannoside derivative 5 DMOS03R Patented Carbohydrates [69]
Biphenyl mannoside derivative 6 DM93VEB Patented Carbohydrates [69]
Biphenyl mannoside derivative 7 DM46NRV Patented Carbohydrates [69]
Biphenyl mannoside derivative 8 DMZCWM5 Patented Carbohydrates [69]
Biphenyl mannoside derivative 9 DMP52HJ Patented Carbohydrates [69]
C-linked disaccharide biphenyl mannoside derivative 1 DMV6H95 Patented Carbohydrates [69]
C-linked disaccharide biphenyl mannoside derivative 2 DMJT1WG Patented Carbohydrates [69]
C-linked disaccharide biphenyl mannoside derivative 3 DMY10T2 Patented Carbohydrates [69]
C-linked disaccharide biphenyl mannoside derivative 4 DMRLE65 Patented Carbohydrates [69]
C-linked disaccharide biphenyl mannoside derivative 5 DMUG7E9 Patented Carbohydrates [69]
C-linked disaccharide biphenyl mannoside derivative 6 DMUILMD Patented Carbohydrates [69]
Mannoside derivative 1 DMIE7U3 Patented Carbohydrates [69]
Mannoside derivative 10 DMZYRHN Patented Carbohydrates [69]
Mannoside derivative 11 DM8I051 Patented Carbohydrates [69]
Mannoside derivative 12 DM4QUY0 Patented Carbohydrates [69]
Mannoside derivative 13 DM0U7P9 Patented Carbohydrates [69]
Mannoside derivative 2 DMFEQD2 Patented Carbohydrates [69]
Mannoside derivative 3 DMPF2UG Patented Carbohydrates [69]
Mannoside derivative 4 DMZBY73 Patented Carbohydrates [69]
Mannoside derivative 5 DMMXNY8 Patented Carbohydrates [69]
Mannoside derivative 6 DMCM3NW Patented Carbohydrates [69]
Mannoside derivative 7 DMOUT1F Patented Carbohydrates [69]
Mannoside derivative 8 DMKTJAH Patented Carbohydrates [69]
Mannoside derivative 9 DMIKZXD Patented Carbohydrates [69]
PMID26651364-Compound-105 DMOJVK6 Patented Carbohydrates [69]
PMID26651364-Compound-106 DMQZJDF Patented Carbohydrates [69]
PMID26651364-Compound-107 DMMZ1WL Patented Carbohydrates [69]
PMID26651364-Compound-108 DMA7D3K Patented Carbohydrates [69]
PMID26651364-Compound-109 DM01IWV Patented Carbohydrates [69]
PMID26651364-Compound-10a DMTPBNY Patented Carbohydrates [69]
PMID26651364-Compound-10b DM16ANH Patented Carbohydrates [69]
PMID26651364-Compound-10c DMCRNWA Patented Carbohydrates [69]
PMID26651364-Compound-10d DMGIV3C Patented Carbohydrates [69]
PMID26651364-Compound-110 DMPA3IX Patented Carbohydrates [69]
PMID26651364-Compound-111 DMY9R58 Patented Carbohydrates [69]
PMID26651364-Compound-112 DM1LIRP Patented Carbohydrates [69]
PMID26651364-Compound-113 DM6OQKM Patented Carbohydrates [69]
PMID26651364-Compound-114 DM5GHJA Patented Carbohydrates [69]
PMID26651364-Compound-115 DMHIA26 Patented Carbohydrates [69]
PMID26651364-Compound-116 DMJ3201 Patented Carbohydrates [69]
PMID26651364-Compound-117a DM6LXHS Patented Carbohydrates [69]
PMID26651364-Compound-117b DMUQSM1 Patented Carbohydrates [69]
PMID26651364-Compound-118 DM6ZRV4 Patented Carbohydrates [69]
PMID26651364-Compound-119 DMONAZI Patented Carbohydrates [69]
PMID26651364-Compound-11b DMGBFK3 Patented Carbohydrates [69]
PMID26651364-Compound-11c DM76WBP Patented Carbohydrates [69]
PMID26651364-Compound-120 DMZTBEQ Patented Carbohydrates [69]
PMID26651364-Compound-121 DM4ZG0Q Patented Carbohydrates [69]
PMID26651364-Compound-122 DMVFTIL Patented Carbohydrates [69]
PMID26651364-Compound-123 DMR0E5W Patented Carbohydrates [69]
PMID26651364-Compound-124 DM6VER5 Patented Carbohydrates [69]
PMID26651364-Compound-125 DMINUDB Patented Carbohydrates [69]
PMID26651364-Compound-126a DMSTKH6 Patented Carbohydrates [69]
PMID26651364-Compound-126b DM2I1QZ Patented Carbohydrates [69]
PMID26651364-Compound-126c DM80PI1 Patented Carbohydrates [69]
PMID26651364-Compound-127 DMEN8RA Patented Carbohydrates [69]
PMID26651364-Compound-128 DM4W0BX Patented Carbohydrates [69]
PMID26651364-Compound-4 DMY0HP1 Patented Carbohydrates [69]
PMID26651364-Compound-45 DMLBZGO Patented Carbohydrates [69]
PMID26651364-Compound-46 DMQFDU8 Patented Carbohydrates [69]
PMID26651364-Compound-47 DM4S5PB Patented Carbohydrates [69]
PMID26651364-Compound-48 DMHXFGU Patented Carbohydrates [69]
PMID26651364-Compound-49 DMMV5A9 Patented Carbohydrates [69]
PMID26651364-Compound-5 DMH7XL3 Patented Carbohydrates [69]
PMID26651364-Compound-50 DM6GFYR Patented Carbohydrates [69]
PMID26651364-Compound-5a DM01GVE Patented Carbohydrates [69]
PMID26651364-Compound-5b DMLHJ1E Patented Carbohydrates [69]
PMID26651364-Compound-5c DMDQTA2 Patented Carbohydrates [69]
PMID26651364-Compound-5d DMF6Z5I Patented Carbohydrates [69]
PMID26651364-Compound-5e DM9TJR5 Patented Carbohydrates [69]
PMID26651364-Compound-5f DMAZIY6 Patented Carbohydrates [69]
PMID26651364-Compound-5g DMSW0HB Patented Carbohydrates [69]
PMID26651364-Compound-6a DM8HAJ3 Patented Carbohydrates [69]
PMID26651364-Compound-6b DMBINOJ Patented Carbohydrates [69]
PMID26651364-Compound-6c DMPF86L Patented Carbohydrates [69]
PMID26651364-Compound-6d DM9J57W Patented Carbohydrates [69]
PMID26651364-Compound-6e DM4LF0X Patented Carbohydrates [69]
PMID26651364-Compound-7a DMQMBY9 Patented Carbohydrates [69]
PMID26651364-Compound-7b DM3LCIM Patented Carbohydrates [69]
PMID26651364-Compound-7c DMGCUJB Patented Carbohydrates [69]
PMID26651364-Compound-7d DM89VQT Patented Carbohydrates [69]
PMID26651364-Compound-7e DM2SZ0B Patented Carbohydrates [69]
PMID26651364-Compound-8a DM1M3WF Patented Carbohydrates [69]
PMID26651364-Compound-8b DMYVU36 Patented Carbohydrates [69]
PMID26651364-Compound-8c DME7UNT Patented Carbohydrates [69]
PMID26651364-Compound-8d DMSO2F8 Patented Carbohydrates [69]
PMID26651364-Compound-9a DMAXWPS Patented Carbohydrates [69]
PMID26651364-Compound-9b DM6HTU0 Patented Carbohydrates [69]
PMID26651364-Compound-9c DM49V8G Patented Carbohydrates [69]
PMID26651364-Compound-9d DMF0L3E Patented Carbohydrates [69]
PMID26651364-Compound-9e DM9FIKD Patented Carbohydrates [69]
PMID26651364-Compound-9f DMF1MV6 Patented Carbohydrates [69]
------------------------------------------------------------------------------------
⏷ Show the Full List of 188 Drug(s)
This Disease is Treated as An Indication in 2 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Pidotimod DMK9BRV Withdrawn from market Small molecular drug [20]
Sulfametopyrazine DMBCK2S Withdrawn from market Small molecular drug [70]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 1 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
mAb926 DMNO20J Preclinical Antibody [71]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 2 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Thiolactomycin DMBAWDG Investigative Small molecular drug [1]
ZP-012 DMKECWK Investigative NA [1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 18 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CAMP TTULOB6 Limited Biomarker [73]
CD248 TTYJWT7 Limited Biomarker [74]
KLK3 TTS78AZ Limited Biomarker [75]
LCN2 TTKTLAI Limited Biomarker [76]
NR3C2 TT26PHO Limited Genetic Variation [77]
DEFB4A TTIVY12 moderate Altered Expression [78]
TLR5 TTCXP8J moderate Altered Expression [79]
TREM1 TTHZQP0 moderate Altered Expression [80]
DAPK3 TTERVQN Strong Biomarker [81]
GPR182 TTT23CG Strong Biomarker [82]
HEXA TTJI5JW Strong Biomarker [83]
IL18 TTRICUF Strong Biomarker [84]
IL1A TTPM6HI Strong Biomarker [84]
LY96 TT8S9AV Strong Biomarker [85]
MBL2 TTMQDZ5 Strong Altered Expression [86]
NOS2 TTF10I9 Strong Biomarker [87]
PCYT1B TTUAIKM Strong Biomarker [88]
POMC TT21AKM Strong Biomarker [89]
------------------------------------------------------------------------------------
⏷ Show the Full List of 18 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC14A2 DT8QC7K Strong Genetic Variation [90]
SLC9A6 DTN0JXW Strong Biomarker [91]
------------------------------------------------------------------------------------
This Disease Is Related to 2 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
NT5C2 DE1DOKJ moderate Biomarker [92]
LARS2 DEP7BTH Strong Biomarker [93]
------------------------------------------------------------------------------------
This Disease Is Related to 40 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
IREB2 OT747D24 Limited Biomarker [94]
AMBP OTLU8GU8 moderate Biomarker [95]
CABIN1 OT4G5CIK moderate Biomarker [79]
CORO7 OTG7MEAJ moderate Biomarker [96]
NHS OTKE8QAT moderate Genetic Variation [97]
NPHS1 OT21JD3P moderate Biomarker [98]
RNASE7 OTIXO0Z4 moderate Biomarker [99]
TCF21 OT393IMA moderate Biomarker [96]
AZU1 OTHXU264 Strong Biomarker [100]
CCL18 OT7JYSK9 Strong Genetic Variation [101]
CTBS OT135K92 Strong Biomarker [88]
CUL9 OTPUCLZT Strong Genetic Variation [101]
CYLD OT37FKH0 Strong Biomarker [102]
DERL2 OTI3TUUZ Strong Genetic Variation [103]
DNAAF3 OT3OHO0O Strong Biomarker [104]
DNAH5 OTC21RUS Strong Biomarker [104]
DNAI1 OTF6C65Q Strong Biomarker [104]
GNLY OTZJKA8C Strong Biomarker [105]
HM13 OTGEO1LP Strong Biomarker [106]
HMX1 OT65ZGE0 Strong Biomarker [107]
IMMP1L OTA6LOLR Strong Biomarker [106]
LARS1 OT4557NF Strong Biomarker [93]
LYPD4 OTYNO8BS Strong Biomarker [108]
MARCHF10 OTAYGHDM Strong Biomarker [109]
MUC7 OTSTMP0X Strong Altered Expression [110]
NLRC4 OTAIA3NA Strong Biomarker [111]
OXA1L OTS0BFRD Strong Biomarker [112]
PACC1 OTKBS8CC Strong Biomarker [113]
PCBD1 OTDSRUD5 Strong Biomarker [104]
PFKM OT1QY9JM Strong Genetic Variation [114]
PLEKHB1 OTC7TNAX Strong Genetic Variation [115]
RNASE1 OTKZ7CO9 Strong Genetic Variation [116]
RRH OTKHIYYT Strong Biomarker [117]
SCNN1G OTSJYQVQ Strong Biomarker [118]
SERPINF2 OTZGAF8B Strong Genetic Variation [119]
SFTPA2 OT6SFOMU Strong Biomarker [120]
SFXN1 OTL66767 Strong Biomarker [110]
SPESP1 OTWXKKTJ Strong Biomarker [121]
SPI1 OTVCA1D0 Strong Biomarker [122]
TNMD OTHLVA9G Strong Biomarker [102]
------------------------------------------------------------------------------------
⏷ Show the Full List of 40 DOT(s)

References

1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018749.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6289).
4 Amoxicillin FDA Label
5 Amphotericin B FDA Label
6 Ampicillin FDA Label
7 Azlocillin FDA Label
8 Aztreonam FDA Label
9 Bacampicillin FDA Label
10 Carbenicillin FDA Label
11 Cefaclor FDA Label
12 Cefadroxil FDA Label
13 Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother. 2009 Dec;53(12):5046-54.
14 Cefamandole FDA Label
15 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
16 Cefixime FDA Label
17 Cefmetazole FDA Label
18 Cefonicid FDA Label
19 [Bacterial pathogens and resistance patterns in community acquired pediatric urinary tract infection: experience of 152 cases]. Zhongguo Dang Dai Er Ke Za Zhi. 2006 Apr;8(2):115-7.
20 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
21 Ceftizoxime FDA Label
22 Cephapirin FDA Label
23 Clavulanate FDA Label
24 Cyclacillin FDA Label
25 Demeclocycline FDA Label
26 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
27 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019616.
28 Erythromycin FDA Label
29 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
30 Fosfomycin FDA Label
31 Prostatectomy and infection. J Urol. 1971 Dec;106(6):910-2.
32 Isolation of Staphylococcus aureus Urinary Tract Infections at a Community-Based Healthcare Center in Riyadh. Cureus. 2023 Feb 18;15(2):e35140.
33 Kanamycin FDA Label
34 Lomefloxacin FDA Label
35 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050549.
36 Minocycline FDA Label
37 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071919.
38 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009175.
39 Norfloxacin FDA Label
40 Ofloxacin FDA Label
41 Oxytetracycline FDA Label
42 Piperacillin FDA Label
43 Drug information of Pivmecillinam, 2008. eduDrugs.
44 In vitro activity of plazomicin against -lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE).J Antimicrob Chemother. 2017 Oct 1;72(10):2792-2795.
45 Polymyxin B Sulfate FDA Label
46 Prulifloxacin: a new antibacterial fluoroquinolone. Expert Rev Anti Infect Ther. 2006 Feb;4(1):27-41.
47 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017569.
48 How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
49 Tetracycline FDA Label
50 Ticarcillin FDA Label
51 Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
52 Trovafloxacin FDA Label
53 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4781).
54 ClinicalTrials.gov (NCT03687255) Safety and Efficacy Study of Cefepime-AAI101 in the Treatment of Complicated Urinary Tract Infections. U.S. National Institutes of Health.
55 ClinicalTrials.gov (NCT04020341) A Study to Evaluate Efficacy and Safety of Gepotidacin in the Treatment of Uncomplicated Urinary Tract Infection (UTI). U.S. National Institutes of Health.
56 ClinicalTrials.gov (NCT03357614) Sulopenem Followed by Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro for Complicated UTI in Adults. U.S. National Institutes of Health.
57 ClinicalTrials.gov (NCT03788967) Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) (ADAPT-PO). U.S. National Institutes of Health.
58 ClinicalTrials.gov (NCT02166476) Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP. U.S. National Institutes of Health.
59 ClinicalTrials.gov (NCT04505683) A Study to Assess Efficacy and Safety Intravenous Benapenem in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP). U.S. National Institutes of Health.
60 ClinicalTrials.gov (NCT03151967) Lactobacillus Probiotic for Prevention of UTI. U.S. National Institutes of Health.
61 ClinicalTrials.gov (NCT01381549) GSK2251052 in Complicated Urinary Tract Infection. U.S. National Institutes of Health.
62 ClinicalTrials.gov (NCT03377426) LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Urinary Tract Infection (cUTI). U.S. National Institutes of Health.
63 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033290)
64 ClinicalTrials.gov (NCT03491748) A Phase 1, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral ETX0282 Administered in Healthy Subjects. U.S.National Institutes of Health.
65 ClinicalTrials.gov (NCT05138822) A Double-Blind, Double Dummy, Randomized, Phase 1b, Nitrofurantoin Controlled, Repeat Oral Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics and Microbiological Response of GSK3882347 in Female Participants With Acute Uncomplicated Urinary Tract Infection. U.S.National Institutes of Health.
66 ClinicalTrials.gov (NCT04191148) Safety, Tolerability, and PK of LBP-EC01 in Patients With Lower Urinary Tract Colonization Caused by E. Coli. U.S. National Institutes of Health.
67 Clinical pipeline report, company report or official report of Roche
68 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
69 Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97.
70 Drug information of Sulfametopyrazine, 2008. eduDrugs.
71 Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471.
72 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
73 Use of ceragenins as a potential treatment for urinary tract infections.BMC Infect Dis. 2019 May 2;19(1):369. doi: 10.1186/s12879-019-3994-3.
74 The frequency of Klebsiella pneumonia encoding genes for CTX-M, TEM-1 and SHV-1 extended-spectrum beta lactamases enzymes isolated from urinary tract infection.Ann Clin Microbiol Antimicrob. 2018 Feb 13;17(1):4. doi: 10.1186/s12941-018-0256-y.
75 Benign Prostatic Hyperplasia Endoscopic Surgical Procedures in Kidney Transplant Recipients: A Comparison Between Holmium Laser Enucleation of the Prostate, GreenLight Photoselective Vaporization of the Prostate, and Transurethral Resection of the Prostate.J Endourol. 2020 Feb;34(2):184-191. doi: 10.1089/end.2019.0430. Epub 2019 Nov 8.
76 Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders.Pediatr Nephrol. 2018 Aug;33(8):1365-1374. doi: 10.1007/s00467-018-3936-0. Epub 2018 Mar 12.
77 Clinical features, genetic background, and outcome in infants with urinary tract infection and type IV renal tubular acidosis.Pediatr Res. 2020 Jun;87(7):1251-1255. doi: 10.1038/s41390-019-0727-7. Epub 2019 Dec 18.
78 Association between vitamin D, antimicrobial peptides and urinary tract infection in infants and young children.Acta Paediatr. 2019 Mar;108(3):551-556. doi: 10.1111/apa.14499. Epub 2018 Aug 7.
79 Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection.Sci Rep. 2019 Jan 14;9(1):106. doi: 10.1038/s41598-018-37482-x.
80 Urine TREM-1 as a marker of urinary tract infection in children.J Int Med Res. 2017 Apr;45(2):631-638. doi: 10.1177/0300060517696199. Epub 2017 Apr 2.
81 Algorithms Using Previous Resistance, Prior Antimicrobial Prescriptions, and Patient Place of Residence Enhance Empirical Therapy for Women With Uncomplicated Urinary Tract Infections.Urology. 2020 Mar;137:72-78. doi: 10.1016/j.urology.2019.11.009. Epub 2019 Nov 17.
82 Implementation of global antimicrobial resistance surveillance system (GLASS) in patients with bacteriuria.J Glob Antimicrob Resist. 2020 Mar;20:60-67. doi: 10.1016/j.jgar.2019.11.009. Epub 2019 Nov 18.
83 Detection of TEM and CTX-M genes from ciprofloxacin resistant Proteus mirabilis and Escherichia coli isolated on urinary tract infections (UTIs).Microb Pathog. 2018 Aug;121:123-130. doi: 10.1016/j.micpath.2018.05.024. Epub 2018 May 17.
84 Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation.BMC Infect Dis. 2009 Jan 26;9:9. doi: 10.1186/1471-2334-9-9.
85 LY96, UPKIB mutations and TLR4, CD14, MBL polymorphisms in children with urinary tract infection.Indian J Pediatr. 2011 Oct;78(10):1229-33. doi: 10.1007/s12098-011-0399-8. Epub 2011 Mar 9.
86 The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants.PLoS One. 2017 May 30;12(5):e0178032. doi: 10.1371/journal.pone.0178032. eCollection 2017.
87 Bacterial infection induces nitric oxide synthase in human neutrophils.J Clin Invest. 1997 Jan 1;99(1):110-6. doi: 10.1172/JCI119121.
88 In Vivo Pharmacodynamic Profile of Ceftibuten-Clavulanate Combination against Extended-Spectrum--Lactamase-Producing Enterobacteriaceae in the Murine Thigh Infection Model.Antimicrob Agents Chemother. 2019 Jun 24;63(7):e00145-19. doi: 10.1128/AAC.00145-19. Print 2019 Jul.
89 Adrenocorticotropic hormone versus methylprednisolone added to interferon in patients with multiple sclerosis experiencing breakthrough disease: a randomized, rater-blinded trial.Ther Adv Neurol Disord. 2017 Jan;10(1):3-17. doi: 10.1177/1756285616670060. Epub 2016 Oct 19.
90 Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection.Int J Immunogenet. 2006 Feb;33(1):49-53. doi: 10.1111/j.1744-313X.2006.00565.x.
91 Erythematous plaques and papules on a premature infant.J Am Acad Dermatol. 2017 Apr;76(4):e111-e112. doi: 10.1016/j.jaad.2016.08.038.
92 Cyclic Di-GMP Signaling Contributes to Pseudomonas aeruginosa-Mediated Catheter-Associated Urinary Tract Infection.J Bacteriol. 2015 Jul 20;198(1):91-7. doi: 10.1128/JB.00410-15. Print 2016 Jan 1.
93 Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.
94 Contribution of yersiniabactin to the virulence of an Escherichia coli sequence type 69 ("clonal group A") cystitis isolate in murine models of urinary tract infection and sepsis.Microb Pathog. 2018 Jul;120:128-131. doi: 10.1016/j.micpath.2018.04.048. Epub 2018 Apr 24.
95 Combination of Coral UTI Screen(TM) system, gram-stain and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for diagnosis of urinary tract infections directly from urine samples.J Chemother. 2019 Apr;31(2):74-80. doi: 10.1080/1120009X.2019.1573284. Epub 2019 Feb 20.
96 Outcomes of Early Removal of Urinary Catheter Following Rectal Resection for Cancer.Ann Surg Oncol. 2019 Jan;26(1):79-85. doi: 10.1245/s10434-018-6822-x. Epub 2018 Oct 23.
97 Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study.BMJ Open. 2019 Apr 20;9(4):e024210. doi: 10.1136/bmjopen-2018-024210.
98 Cytotoxic Necrotizing Factor-1 (CNF1) does not promote E. coli infection in a murine model of ascending pyelonephritis.BMC Microbiol. 2017 May 25;17(1):127. doi: 10.1186/s12866-017-1036-0.
99 Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection.J Am Soc Nephrol. 2019 Aug;30(8):1385-1397. doi: 10.1681/ASN.2018090929. Epub 2019 Jun 25.
100 New markers of urinary tract infection.Clin Chim Acta. 2017 Aug;471:286-291. doi: 10.1016/j.cca.2017.06.003. Epub 2017 Jun 13.
101 High frequency of aac(6')-Ib-cr gene associated with double mutations in gyrA and parC in Escherichia coli isolates from patients with urinary tract infections.J Glob Antimicrob Resist. 2018 Jun;13:180-183. doi: 10.1016/j.jgar.2017.12.013. Epub 2018 Jan 4.
102 Carbapenem-Resistant KPC- and TEM-Producing Escherichia coli ST131 Isolated from a Hospitalized Patient with Urinary Tract Infection: First Isolation in Molise Region, Central Italy, July 2018.Microb Drug Resist. 2020 Jan;26(1):38-45. doi: 10.1089/mdr.2019.0085. Epub 2019 Aug 6.
103 Impact of enterococcal urinary tract infections in immunocompromised - neoplastic patients.J BUON. 2019 Sep-Oct;24(5):1768-1775.
104 Is there a conflict between general practitioners applying guidelines for antibiotic prescribing and including their patients' preferences?.Patient Prefer Adherence. 2017 Dec 21;12:9-19. doi: 10.2147/PPA.S147616. eCollection 2018.
105 The selective biomarker IL-8 identifies IFTA after kidney transplantation in blood cells.Transpl Immunol. 2016 Nov;39:18-24. doi: 10.1016/j.trim.2016.09.003. Epub 2016 Sep 29.
106 Detection of VIM-1 and IMP-1 genes in Klebsiella pneumoniae and relationship with biofilm formation.Microb Pathog. 2018 Feb;115:25-30. doi: 10.1016/j.micpath.2017.12.036. Epub 2017 Dec 14.
107 MiR-204/miR-211 downregulation contributes to candidemia-induced kidney injuries via derepression of Hmx1 expression.Life Sci. 2014 May 2;102(2):139-44. doi: 10.1016/j.lfs.2014.03.010. Epub 2014 Mar 15.
108 YnfA , a SMR family efflux pump is abundant in Escherichia coli isolates from urinary infection.Indian J Med Microbiol. 2015 Jan-Mar;33(1):139-42. doi: 10.4103/0255-0857.148415.
109 Prevalence and predictive factors of urinary tract infection among patients with stroke: A meta-analysis.Am J Infect Control. 2018 Apr;46(4):402-409. doi: 10.1016/j.ajic.2017.10.001. Epub 2017 Nov 16.
110 Detection of circulating MUC7-positive cells by reverse transcription-polymerase chain reaction in bladder cancer patients.Int J Urol. 2004 Jan;11(1):38-43. doi: 10.1111/j.1442-2042.2004.00739.x.
111 Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections.Front Microbiol. 2019 Sep 3;10:2020. doi: 10.3389/fmicb.2019.02020. eCollection 2019.
112 Molecular characteristics of extended-spectrum beta-lactamase-producing Escherichia coli from the Chicago area: high prevalence of ST131 producing CTX-M-15 in community hospitals.Int J Antimicrob Agents. 2010 Jul;36(1):19-23. doi: 10.1016/j.ijantimicag.2010.02.016. Epub 2010 Mar 31.
113 Antiadhesive Activity and Metabolomics Analysis of Rat Urine after Cranberry (Vaccinium macrocarpon Aiton) Administration.J Agric Food Chem. 2017 Jul 19;65(28):5657-5667. doi: 10.1021/acs.jafc.7b01856. Epub 2017 Jul 5.
114 Flexible Metabolism and Suppression of Latent Enzymes Are Important for Escherichia coli Adaptation to Diverse Environments within the Host.J Bacteriol. 2019 Jul 24;201(16):e00181-19. doi: 10.1128/JB.00181-19. Print 2019 Aug 15.
115 Contribution of fucose-containing capsules in Klebsiella pneumoniae to bacterial virulence in mice.Exp Biol Med (Maywood). 2008 Jan;233(1):64-70. doi: 10.3181/0706-RM-170.
116 The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection.Front Immunol. 2019 Nov 29;10:2786. doi: 10.3389/fimmu.2019.02786. eCollection 2019.
117 Comparative analysis of genitourinary function after type C1 robotic nerve-sparing radical hysterectomy versus type C2 robotic radical hysterectomy.Surg Oncol. 2019 Sep;30:58-62. doi: 10.1016/j.suronc.2019.05.003. Epub 2019 May 11.
118 Transient pseudohypoaldosteronism in infancy secondary to urinary tract infection.J Paediatr Child Health. 2017 May;53(5):458-463. doi: 10.1111/jpc.13481. Epub 2017 Feb 24.
119 Aerococcus urinae and Aerococcus sanguinicola, two frequently misidentified uropathogens.Scand J Infect Dis. 2010 Oct;42(10):775-80. doi: 10.3109/00365548.2010.485576.
120 Innate immunity of surfactant proteins A and D in urinary tract infection with uropathogenic Escherichia coli.Innate Immun. 2016 Jan;22(1):9-20. doi: 10.1177/1753425915609973. Epub 2015 Oct 28.
121 Survey for virulence determinants among Enterococcus faecalis isolated from different sources.J Med Microbiol. 2004 Jan;53(Pt 1):13-20. doi: 10.1099/jmm.0.05353-0.
122 The Escherichia coli Type III Secretion System 2 Has a Global Effect on Cell Surface.mBio. 2018 Jul 3;9(4):e01070-18. doi: 10.1128/mBio.01070-18.