General Information of Drug (ID: DMOHS9P)

Drug Name
Phenacemide
Synonyms
Acetylureum; Carbanmide; Cetylureum; Comitiadone; Eferon; Efron; Epheron; Epiclase; Felurea; Fenacemid; Fenacemida; Fenacemide;Fenacetamide; Fenilep; Fenised; Fenostenyl; Fenural; Fenurea; Fenurone; Fenylacetylmocovina; Fenytan; Neophedan; Neophenal; Phacetur; Phenacalum; Phenacemidum; Phenacereum; Phenacerum; Phenacetur; Phenacetylcarbamide; Phenacetylurea; Phenarone; Phenicarb; Phenuron; Phenurone; Phenutal; Phenylacetylurea; Phenylacetyluree; Phenyrit; Phetylureum; Carbamide phenylacetate; Fenacemide [DCIT]; Fenylacetylmocovina [Czech]; Phenylacetyluree [French]; A-1348; Alpha-Phenylacetylurea; Fenacemida [INN-Spanish]; Fenacetil-karbamide; Phenacemide [INN:BAN]; Phenacemidum [INN-Latin]; Phenurone (TN); Sym-PHENYLACETYLUREA; N-(Aminocarbonyl)benzeneacetamide; Phenacemide (JAN/INN); N-carbamoyl-2-phenylacetamide; N-(aminocarbonyl)-2-phenylacetamide; (2-phenylacetyl)urea; (Phenylacetyl)urea
Indication
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Approved [1]
Therapeutic Class
Anticonvulsants
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 178.19
Logarithm of the Partition Coefficient (xlogp) 0.9
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 2
ADMET Property
Absorption
The drug is almost completely absorbed []
Half-life
The concentration or amount of drug in body reduced by one-half in 22 - 25 hours [2]
Metabolism
The drug is metabolized via the liver []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 280.59583 micromolar/kg/day [3]
Chemical Identifiers
Formula
C9H10N2O2
IUPAC Name
N-carbamoyl-2-phenylacetamide
Canonical SMILES
C1=CC=C(C=C1)CC(=O)NC(=O)N
InChI
InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13)
InChIKey
XPFRXWCVYUEORT-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4753
ChEBI ID
CHEBI:8049
CAS Number
63-98-9
DrugBank ID
DB01121
TTD ID
D07ONP

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Blocker [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Phenacemide (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Levomilnacipran DMV26S8 Moderate Antagonize the effect of Phenacemide when combined with Levomilnacipran. Chronic pain [MG30] [5]
Vilazodone DM4LECQ Moderate Antagonize the effect of Phenacemide when combined with Vilazodone. Depression [6A70-6A7Z] [5]
Vortioxetine DM6F1PU Moderate Antagonize the effect of Phenacemide when combined with Vortioxetine. Depression [6A70-6A7Z] [5]
Milnacipran DMBFE74 Moderate Antagonize the effect of Phenacemide when combined with Milnacipran. Depression [6A70-6A7Z] [5]
Escitalopram DMFK9HG Moderate Antagonize the effect of Phenacemide when combined with Escitalopram. Depression [6A70-6A7Z] [5]
Desvenlafaxine DMHD4PE Moderate Antagonize the effect of Phenacemide when combined with Desvenlafaxine. Depression [6A70-6A7Z] [5]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Phenacemide and Esketamine. Depression [6A70-6A7Z] [6]
Hydroxychloroquine DMSIVND Moderate Antagonize the effect of Phenacemide when combined with Hydroxychloroquine. Malaria [1F40-1F45] [6]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Phenacemide and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [7]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Phenacemide and Lasmiditan. Migraine [8A80] [8]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Phenacemide and Flibanserin. Mood disorder [6A60-6E23] [9]
⏷ Show the Full List of 11 DDI Information of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7265).
2 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Belcastro V, Costa C, Striano P "Levetiracetam-associated hyponatremia." Seizure 17 (2008): 389-90. [PMID: 18584781]
6 Cerner Multum, Inc. "Australian Product Information.".
7 Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
8 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
9 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.