General Information of Drug (ID: DMQ95GE)

Drug Name
Phenylacetic acid
Synonyms
.alpha.-Toluic acid; .omega.-Phenylacetic acid; 2-Phenylacetic acid; Acetic acid, phenyl-; Benzenacetic acid; Benzeneacetic acid; Benzylcarboxylic acid; Benzylformic acid; Kyselina fenyloctova; Kyselina fenyloctova [Czech]; PHENYL ACETIC ACID; PHENYL-ACETIC ACID; PHENYLACETIC ACID; Phenylacetic acid (natural); Phenylethanoic acid; Phenyllacetic acid; alpha-Toluic acid; omega-Phenylacetic acid; phenylacetate
Indication
Disease Entry ICD 11 Status REF
Hepatic encephalopathy DB99.5 Approved [1]
Ornithine transcarbamylase deficiency 5C50.AY Approved [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 136.15
Logarithm of the Partition Coefficient (xlogp) 1.4
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 2
ADMET Property
Metabolism
The drug is metabolized via the liver []
Vd
The volume of distribution (Vd) of drug is 19.2 +/- 3.3 L []
Chemical Identifiers
Formula
C8H8O2
IUPAC Name
2-phenylacetic acid
Canonical SMILES
C1=CC=C(C=C1)CC(=O)O
InChI
InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)
InChIKey
WLJVXDMOQOGPHL-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
999
ChEBI ID
ChEBI:30745
CAS Number
103-82-2
DrugBank ID
DB09269
VARIDT ID
DR00333
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Monocarboxylate transporter 3 (SLC16A8) DT39AOM MOT3_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Biotransformations [4]
Serum paraoxonase/arylesterase 2 (PON2) OT55NCTD PON2_HUMAN Biotransformations [4]
Serum paraoxonase/lactonase 3 (PON3) OT80W9TA PON3_HUMAN Biotransformations [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events. Clin Pharmacokinet. 2021 Dec;60(12):1557-1567.
2 Glycerol Phenylbutyrate (Ravicti). Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr.
3 Immunohistochemical and functional characterization of peptide, organic cation, neutral and basic amino acid, and monocarboxylate drug transporters in human ocular tissues. Drug Metab Dispos. 2013 Feb;41(2):466-74.
4 Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women. Chin Med J (Engl). 2005 Jul 20;118(14):1167-74.
5 Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product. Biochem Pharmacol. 2005 Oct 1;70(7):1019-25. doi: 10.1016/j.bcp.2005.07.004.