General Information of Drug (ID: DMRE4FC)

Drug Name
Arginine
Synonyms
DL-Arginine hydrochloride; 32042-43-6; 2-Amino-5-guanidinopentanoic acid hydrochloride; argininhydrochlorid; DL-Arginine HCl; 220144-84-3; H-DL-Arg-OH.xHCl; DL-(+/-)-Arginine Hydrochloride; 1-Hydrochloride arginine; NSC7914; Arginine monochloride; 2-Amino-5-guanidinovaleric acid monohydrochloride; WLN: MUYZM3YZVQ & DL-Arginine hydrochloride, 98%, anhydrous; Arginine monohydrochloride, L-(+)-; ARGININE, (L); L(+)-Arginine hydrochloride; D-Arginine, hydrochloride (1:1); EINECS 250-903-0; EINECS 239-674-8
Indication
Disease Entry ICD 11 Status REF
Growth hormone deficiency 5A61.3 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 174.2
Logarithm of the Partition Coefficient (xlogp) -4.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Bioavailability
68% of drug becomes completely available to its intended biological destination(s) [2]
Metabolism
The drug is not metabolised []
Chemical Identifiers
Formula
C6H14N4O2
IUPAC Name
(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid
Canonical SMILES
C(C[C@@H](C(=O)O)N)CN=C(N)N
InChI
InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChIKey
ODKSFYDXXFIFQN-BYPYZUCNSA-N
Cross-matching ID
PubChem CID
6322
ChEBI ID
CHEBI:16467
CAS Number
74-79-3
DrugBank ID
DB00125
TTD ID
D0F5DO
VARIDT ID
DR00188

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Mitochondrial ornithine transporter 2 (SLC25A2) DTDPJ3F ORNT2_HUMAN Substrate [3]
Sodium-coupled neutral amino acid transporter 9 (SLC38A9) DTF7MYK S38A9_HUMAN Substrate [4]
Mitochondrial ornithine transporter 3 (SLC25A29) DT96BT4 MCATL_HUMAN Substrate [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches
3 Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2. Amino Acids. 2016 Feb;48(2):427-36.
4 Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94.
5 The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84.